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Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial

  • 2013-04-25
  • British Journal of Nutrition 110(9)
    • Y. Kadooka
    • Masao Sato
    • A. Ogawa
    • M. Miyoshi
    • H. Uenishi
    • Hitomi Ogawa
    • Ken Ikuyama
    • M. Kagoshima
    • T. Tsuchida

Abstract

Consumption of fermented milk (FM) containing a probiotic, Lactobacillus gasseri SBT2055 (LG2055), previously showed a reduction in abdominal adiposity in a randomised controlled trial (RCT) using FM with 10(8) colony-forming units (cfu) of LG2055/g. However, whether the effectiveness is observed at lower concentrations, the recommended minimum or intermediate levels of probiotics (10(6) or 10(7) cfu/g, respectively), remains to be examined. A multi-centre, double-blind, parallel-group RCT was conducted using 210 healthy Japanese adults with large visceral fat areas (80·2 - 187·8 cm(2)). They were balanced for their baseline characteristics and randomly assigned to three groups receiving FM containing 10(7), 10(6) or 0 (control) cfu LG2055/g of FM, and were asked to consume 200 g FM/d for 12 weeks. Abdominal visceral fat areas, which were determined by computed tomography, at week 12, changed from baseline by an average of -8·5 % (95 % CI -11·9, -5·1; P< 0·01) in the 10(7) dose group, and by -8·2 % (95 % CI -10·8, -5·7; P< 0·01) in the 10(6) dose group. Other measures including BMI, waist and hip circumferences, and body fat mass were also significantly decreased from baseline at week 12 in both groups; interestingly, the cessation of taking FM for 4 weeks attenuated these effects. In the control group, none of these parameters significantly decreased from baseline. These findings demonstrate that consumption of LG2055 at doses as low as the order of 10(8) cfu/d exhibited a significant lowering effect on abdominal adiposity, and suggest that constant consumption might be needed to maintain the effect.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriReduced Abdominal AdiposityBeneficial
Large
Lactobacillus gasseriReduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseriReduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseriReduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseriReduced Waist CircumferenceBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced Abdominal AdiposityBeneficial
Large
Lactobacillus gasseri LAC-343Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Waist CircumferenceBeneficial
Moderate
Lactobacillus gasseri LAC-343Sustained Effects with Ongoing ConsumptionBeneficial
Small
Lactobacillus gasseri LBV 150NAttenuation of Health Effects After CessationNeutral
Moderate
Lactobacillus gasseri LBV 150NReduced Abdominal AdiposityBeneficial
Large
Lactobacillus gasseri LBV 150NReduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Waist CircumferenceBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Abdominal AdiposityBeneficial
Large
Lactobacillus gasseri LG-36Reduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Waist CircumferenceBeneficial
Moderate
Lactobacillus gasseri SD-5585Lapse in Effect Post-CessationNeutral
Moderate
Lactobacillus gasseri SD-5585Reduced Abdominal AdiposityBeneficial
Large
Lactobacillus gasseri SD-5585Reduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Waist CircumferenceBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Abdominal FatBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Body Fat MassBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Body Mass IndexBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Hip CircumferenceBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Waist CircumferenceBeneficial
Moderate
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