Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers.
- 2002-12
- The American Journal of Clinical Nutrition 76(6)
- M. Naruszewicz
- M. Johansson
- D. Zapolska-Downar
- H. Bukowska
- PubMed: 12450890
- DOI: 10.1093/AJCN/76.6.1249
Abstract
Background: The short-chain fatty acids formed in the human colon by the bacterial fermentation of fiber may have an antiinflammatory effect, may reduce insulin production, and may improve lipid metabolism. We previously showed in hypercholesterolemic patients that supplementation with the probiotic bacteria Lactobacillus plantarum 299v significantly lowers concentrations of LDL cholesterol and fibrinogen.
Objective: We determined the influence of a functional food product containing L. plantarum 299v on lipid profiles, inflammatory markers, and monocyte function in heavy smokers.
Design: Thirty-six healthy volunteers (18 women and 18 men) aged 35-45 y participated in a controlled, randomized, double-blind trial. The experimental group drank 400 mL/d of a rose-hip drink containing L. plantarum 299v (5 x 10(7) colony-forming units/mL); the control group consumed the same volume of product without bacteria. The experiment lasted 6 wk and entailed no changes in lifestyle.
Results: Significant decreases in systolic blood pressure (P < 0.000), leptin (P < 0.000), and fibrinogen (P < 0.001) were recorded in the experimental group. No such changes were observed in the control group. Decreases in F(2)-isoprostanes (37%) and interleukin 6 (42%) were also noted in the experimental group in comparison with baseline. Monocytes isolated from subjects treated with L. plantarum showed significantly reduced adhesion (P < 0.001) to native and stimulated human umbilical vein endothelial cells.
Conclusion: L. plantarum administration leads to a reduction in cardiovascular disease risk factors and could be useful as a protective agent in the primary prevention of atherosclerosis in smokers.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus plantarum 299v | Reduced F2-Isoprostanes | Beneficial | Moderate |
| Lactobacillus plantarum 299v | Reduced Fibrinogen Levels | Beneficial | Large |
| Lactobacillus plantarum 299v | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Lactobacillus plantarum 299v | Reduced Leptin Levels | Beneficial | Large |
| Lactobacillus plantarum 299v | Reduced Monocyte Adhesion | Beneficial | Large |
| Lactobacillus plantarum 299v | Reduced Systolic Blood Pressure | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced Blood Leptin Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced Blood Pressure | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced F2-Isoprostanes | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Fibrinogen Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Monocyte Adhesion | Beneficial | Large |
| Lactobacillus plantarum DSM 6596 | Reduced F2-Isoprostanes | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Fibrinogen Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6596 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Leptin Levels | Beneficial | Large |
| Lactobacillus plantarum DSM 6596 | Reduced Monocyte Adhesion | Beneficial | Large |
| Lactobacillus plantarum DSM 6596 | Reduced Systolic Blood Pressure | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced F2-Isoprostanes | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Fibrinogen Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Leptin Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced Monocyte Adhesion | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced Systolic Blood Pressure | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced F2-Isoprostanes | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Reduced Fibrinogen Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced Interleukin-6 Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Reduced Leptin Levels | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced Monocyte Adhesion | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced Systolic Blood Pressure | Beneficial | Large |