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Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers.

  • 2002-12
  • The American Journal of Clinical Nutrition 76(6)
    • M. Naruszewicz
    • M. Johansson
    • D. Zapolska-Downar
    • H. Bukowska

Abstract

Background: The short-chain fatty acids formed in the human colon by the bacterial fermentation of fiber may have an antiinflammatory effect, may reduce insulin production, and may improve lipid metabolism. We previously showed in hypercholesterolemic patients that supplementation with the probiotic bacteria Lactobacillus plantarum 299v significantly lowers concentrations of LDL cholesterol and fibrinogen.

Objective: We determined the influence of a functional food product containing L. plantarum 299v on lipid profiles, inflammatory markers, and monocyte function in heavy smokers.

Design: Thirty-six healthy volunteers (18 women and 18 men) aged 35-45 y participated in a controlled, randomized, double-blind trial. The experimental group drank 400 mL/d of a rose-hip drink containing L. plantarum 299v (5 x 10(7) colony-forming units/mL); the control group consumed the same volume of product without bacteria. The experiment lasted 6 wk and entailed no changes in lifestyle.

Results: Significant decreases in systolic blood pressure (P < 0.000), leptin (P < 0.000), and fibrinogen (P < 0.001) were recorded in the experimental group. No such changes were observed in the control group. Decreases in F(2)-isoprostanes (37%) and interleukin 6 (42%) were also noted in the experimental group in comparison with baseline. Monocytes isolated from subjects treated with L. plantarum showed significantly reduced adhesion (P < 0.001) to native and stimulated human umbilical vein endothelial cells.

Conclusion: L. plantarum administration leads to a reduction in cardiovascular disease risk factors and could be useful as a protective agent in the primary prevention of atherosclerosis in smokers.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum 299vReduced F2-IsoprostanesBeneficial
Moderate
Lactobacillus plantarum 299vReduced Fibrinogen LevelsBeneficial
Large
Lactobacillus plantarum 299vReduced Interleukin-6 LevelsBeneficial
Moderate
Lactobacillus plantarum 299vReduced Leptin LevelsBeneficial
Large
Lactobacillus plantarum 299vReduced Monocyte AdhesionBeneficial
Large
Lactobacillus plantarum 299vReduced Systolic Blood PressureBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced Blood Leptin LevelsBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced Blood PressureBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced F2-IsoprostanesBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Fibrinogen LevelsBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced Interleukin-6 LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Monocyte AdhesionBeneficial
Large
Lactobacillus plantarum DSM 6596Reduced F2-IsoprostanesBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Fibrinogen LevelsBeneficial
Large
Lactobacillus plantarum DSM 6596Reduced Interleukin-6 LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Leptin LevelsBeneficial
Large
Lactobacillus plantarum DSM 6596Reduced Monocyte AdhesionBeneficial
Large
Lactobacillus plantarum DSM 6596Reduced Systolic Blood PressureBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced F2-IsoprostanesBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Fibrinogen LevelsBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced Interleukin-6 LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Leptin LevelsBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced Monocyte AdhesionBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced Systolic Blood PressureBeneficial
Large
Lactobacillus plantarum Rosell-AReduced F2-IsoprostanesBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Fibrinogen LevelsBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Interleukin-6 LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Leptin LevelsBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Monocyte AdhesionBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Systolic Blood PressureBeneficial
Large
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