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Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women

  • 2013-12-03
  • British Journal of Nutrition 111(8)
    • Marina Sánchez
    • C. Darimont
    • V. Drapeau
    • S. Emady-Azar
    • Mélissa Lepage
    • E. Rezzonico
    • C. Ngom-Bru
    • B. Berger
    • Lionel Philippe
    • Corinne Ammon-Zuffrey
    • P. Leone
    • Geneviève Chevrier
    • Emmanuelle St-Amand
    • A. Marette
    • Jean Doré
    • A. Tremblay

Abstract

The present study investigated the impact of a Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and maintenance in obese men and women over 24 weeks. In a double-blind, placebo-controlled, randomised trial, each subject consumed two capsules per d of either a placebo or a LPR formulation (1.6 × 10(8) colony-forming units of LPR/capsule with oligofructose and inulin). Each group was submitted to moderate energy restriction for the first 12 weeks followed by 12 weeks of weight maintenance. Body weight and composition were measured at baseline, at week 12 and at week 24. The intention-to-treat analysis showed that after the first 12 weeks and after 24 weeks, mean weight loss was not significantly different between the LPR and placebo groups when all the subjects were considered. However, a significant treatment × sex interaction was observed. The mean weight loss in women in the LPR group was significantly higher than that in women in the placebo group (P = 0.02) after the first 12 weeks, whereas it was similar in men in the two groups (P= 0.53). Women in the LPR group continued to lose body weight and fat mass during the weight-maintenance period, whereas opposite changes were observed in the placebo group. Changes in body weight and fat mass during the weight-maintenance period were similar in men in both the groups. LPR-induced weight loss in women was associated not only with significant reductions in fat mass and circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in faeces. The present study shows that the Lactobacillus rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable weight loss.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus CLR1505Increased Lachnospiraceae Species AbundanceNeutral
Small
Lactobacillus rhamnosus CLR1505Reduced Blood Leptin LevelsBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Body Fat MassBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Blood Leptin LevelsBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Body Fat MassBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus LR06Maintained WeightBeneficial
Moderate
Lactobacillus rhamnosus LR06Modulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Body Fat MassBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Circulating Leptin ConcentrationsBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Increased Lachnospiraceae Bacterial LevelsNeutral
Small
Lactobacillus rhamnosus Lr-32Reduced Body Fat MassBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Reduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Reduced Leptin LevelsBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RReduced Body Fat MassBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RReduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RReduced Circulating Leptin ConcentrationsBeneficial
Moderate

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