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Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome.

  • 2010-04
  • Annals of Allergy, Asthma & Immunology 104(4)
    • S. Woo
    • Ji-Yon Kim
    • Yong-Ju Lee
    • Nam-Shik Kim
    • Y. Hahn


Background: Probiotics have been suggested to be useful in children with atopic eczema-dermatitis syndrome (AEDS).

Objective: To assess the clinical effect of Lactobacillus sakei supplementation in children with AEDS.

Methods: In a double-blind, placebo-controlled trial, children aged 2 to 10 years with AEDS with a minimum SCORing of Atopic Dermatitis (SCORAD) score of 25 were randomized to receive either daily L sakei KCTC 10755BP or daily placebo supplementation for 12 weeks. Changes in SCORAD scores and serum chemokine levels from baseline were evaluated.

Results: Eighty-eight children were enrolled, and 45 were allocated to probiotic treatment. Seventy-five children completed the study, with 4 dropouts in the probiotic group and 9 in the placebo group. At week 12, SCORAD total scores adjusted by pretreatment values were lower after probiotic treatment than after placebo treatment (P = .01). There was a 31% (13.1-point) improvement in mean disease activity with probiotic use compared with a 13% (5.2-point) improvement with placebo use (P = .008). Significant differences in favor of probiotic treatment were also observed in proportions of patients achieving improvement of at least 30% and 50%. Compared with placebo, probiotic administration was associated with lower pretreatment-adjusted serum levels of CCL17 and CCL27 (P =.03 for both), which were significantly correlated with SCORAD total score (r = 0.59 and 0.63, respectively; P < .001).

Conclusions: Supplementation of L sakei in children with AEDS was associated with a substantial clinical improvement and a significant decrease in chemokine levels, reflecting the severity of AEDS.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus sakei proBio65Improved Atopic Eczema-Dermatitis SymptomsBeneficial
Lactobacillus sakei proBio65Reduced Serum Chemokine LevelsBeneficial

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