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Effect of Milk Fermented with Lactobacillus acidophilus Strain L-92 on Symptoms of Japanese Cedar Pollen Allergy: A Randomized Placebo-Controlled Trial

  • 2005-01
  • Bioscience, Biotechnology, and Biochemistry 69(9)
    • Y. Ishida
    • F. Nakamura
    • H. Kanzato
    • D. Sawada
    • N. Yamamoto
    • H. Kagata
    • M. Oh-Ida
    • Haruo Takeuchi
    • S. Fujiwara


A placebo-controlled, single-blind study was conducted to evaluate the effects of Lactobacillus acidophilus strain L-92 (L-92) on the symptoms of Japanese cedar-pollen allergy. This study was carried out during the 2002 and 2003 seasons of Japanese cedar pollination. Twenty-three in-house volunteers were asked to drink 100 ml of heat-treated milk fermented with L-92 containing 5 x 10(10) of the bacteria, twice a day, for 6 consecutive weeks. A similar study was carried out during the 2003 season for 10 weeks, but the daily dose of bacteria was 2 x 10(10). A significant improvement of the ocular symptom-medication score (SMS) was observed in 2002 and of the score of distress of life in 2003. These data show that a daily oral intake of not less than 2 x 10(10) heat-treated L-92 cells improved the symptoms of Japanese cedar pollinosis, thereby contributing to reduce the dose of concomitant medications. However, no blood parameter was significantly affected in these trials.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus acidophilus L-92Improved Distress of Life ScoreBeneficial
Lactobacillus acidophilus L-92Reduced Concomitant Medication UsageBeneficial
Lactobacillus acidophilus L-92Reduced Ocular Symptoms of Japanese Cedar PollinosisBeneficial

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