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Abstract

Irritable bowel syndrome (IBS) causes intestinal discomfort, gut dysfunction, and poor quality of life. This randomized, double-blind placebo-controlled trial evaluated the efficacy of Lactiplantibacillus (Lp., formerly Lactobacillus) plantarum APsulloc 331261 (GTB1TM) from green tea leaves in participants with diarrhea-predominant irritable bowel syndrome (IBS-D). Twenty-seven participants meeting the Rome IV diagnostic criteria were randomized for GTB1 or placebo ingestion for four weeks and follow-up for two weeks. The efficacy endpoints included adequate global relief of symptoms, assessment of intestinal discomfort symptom severity and frequency, stool frequency, satisfaction, and fecal microbiome abundance. Of all participants, 94.4% and 62.5% reported global relief of symptoms in the GTB1 and placebo groups, respectively, with significant differences (p = 0.037). GTB1 significantly reduced the severity and frequency of abdominal pain, bloating, and feeling of incomplete evacuation. The frequencies of diarrhea were decreased -45.89% and -26.76% in the GTB1 and placebo groups, respectively (p = 0.045). Hence, GTB1 ingestion improved IBS-D patient quality of life. After four weeks treatment, the relative abundance of Lactobacillus was higher in the GTB1 than in the placebo group (p = 0.010). Our results showed that GTB1 enhanced intestinal discomfort symptoms, defecation consistency, quality of life, beneficial microbiota, and overall intestinal health.

Keywords: Lactiplantibacillus plantarum APsulloc 331261 (GTB1); diarrhea; green tea; irritable bowel syndrome.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarumGlobal Relief of IBS SymptomsBeneficial
Moderate
Lactiplantibacillus plantarumImproved Intestinal FunctionBeneficial
Moderate
Lactiplantibacillus plantarumIncreased Fecal LactobacilliBeneficial
Moderate
Lactiplantibacillus plantarumReduced Abdominal PainBeneficial
Small
Lactiplantibacillus plantarumReduced BloatingBeneficial
Moderate
Lactiplantibacillus plantarumReduced Diarrhea FrequencyBeneficial
Moderate
Lactiplantibacillus plantarumReduced Sense of Incomplete EvacuationBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved General IBS SymptomsBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Quality of LifeBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Increased Beneficial Gut MicrobiotaBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Reduced Abdominal PainBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Reduced Diarrhea FrequencyBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Global Relief of IBS SymptomsBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Quality of Life for IBS-D PatientsBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Increased Beneficial Gut MicrobiotaBeneficial
Small
Lactiplantibacillus plantarum KABP™-023Reduced Diarrhea FrequencyBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Global Relief of IBS SymptomsBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Improved Quality of Life for IBS-D PatientsBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Increased Fecal LactobacilliBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Diarrhea FrequencyBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Overall Gastrointestinal HealthBeneficial
Large
Lactiplantibacillus plantarum LP-1Improved Quality of LifeBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Symptom Relief in IBS-D PatientsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Fecal LactobacilliBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Diarrhea FrequencyBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Global Relief of IBS SymptomsBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Increased Relative Abundance of Beneficial Microbiota (Lactobacillus)Beneficial
Moderate
Lactiplantibacillus plantarum Lp-115Reduced Diarrhea FrequencyBeneficial
Moderate

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