Effect of orally administered Lactobacillus brevis HY7401 in a food allergy mouse model.
- 2013-11
- Journal of Microbiology and Biotechnology 23(11)
- Jeongmin Lee
- Jieun Bang
- H. Woo
- PubMed: 23985541
- DOI: 10.4014/JMB.1306.06047
Study Design
- Type
- Clinical Trial
- Population
- OVA-T cell receptor transgenic mice
- Methods
- In vivo experiment with mice
- Animal Study
Abstract
We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
Research Insights
These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
- Effect
- Beneficial
- Effect size
- Moderate
All assayed isotypes of OVA-specific antibody were effectively reduced.
- Effect
- Beneficial
- Effect size
- Large
Systemic anaphylaxis was also relatively reduced with the probiotic administration.
- Effect
- Beneficial
- Effect size
- Moderate
This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines.
- Effect
- Beneficial
- Effect size
- Moderate
This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines.
- Effect
- Beneficial
- Effect size
- Moderate
This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines.
- Effect
- Beneficial
- Effect size
- Moderate