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Abstract

Objective : (1) To investigate the effect of probiotic bacterium Lactobacillus paracasei SD1 on the level of salivary mutans streptococci and lactobacilli, and (2) the oral persistence of L. paracasei SD1 in orthodontically treated nonsyndromic cleft lip and palate patients. Design : Double-blinded, randomized, placebo-controlled study. Participants : A total of 30 orthodontically treated nonsyndromic cleft lip and palate patients (aged 19.22 ± 3.66 years): 15 in the intervention group (A) and 15 in the control group (B). Interventions : Milk with or without L. paracasei SD1. Average daily consumption of milk in both groups was 50 mL for 4 weeks. Main Outcome Measures : Salivary mutans streptococci and lactobacilli were enumerated using a quantitative differential culture at baseline and once a week after the end of the administration period for 4 weeks. The persistence of L. paracasei SD1 was traced using arbitrarily primed polymerase chain reaction of the DNA fingerprinting. Results : A statistically significant reduction in mutans streptococci counts occurred in group A, in contrast to group B (P < .001). A significant increase of lactobacilli numbers was found in group A (P < .001), and L. paracasei SD1 could be detected up to 4 weeks following cessation of dosing. Conclusions : The probiotic milk powder containing L. paracasei SD1 could reduce mutans streptococci counts and was apparently able to colonize the oral cavity of the orthodontically treated cleft lip and palate patients. However, the potentially beneficial influence of the probiotic milk on the complex oral microflora justifies further studies with a larger group of volunteers.

Keywords: Lactobacillus paracasei SD1; cleft lip and palate; mutans streptococci; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus casei SD-5213Increased Fecal LactobacilliBeneficial
Large
Lactobacillus casei SD-5213Reduced Mutans Streptococcus CountsBeneficial
Large
Lactobacillus paracasei 431Increased Colonization by Lactobacillus paracasei SD1Beneficial
Large
Lactobacillus paracasei 431Increased Lactobacilli LevelsBeneficial
Large
Lactobacillus paracasei 431Reduced Mutans Streptococcus CountsBeneficial
Large
Lactobacillus paracasei DSM 13434Increased Lactobacillus CountsBeneficial
Large
Lactobacillus paracasei DSM 13434Reduced Mutans Streptococcus CountsBeneficial
Large
Lactobacillus paracasei HA-196Increased Fecal LactobacilliBeneficial
Large
Lactobacillus paracasei HA-196Reduced Mutans Streptococci LevelsBeneficial
Large
Lactobacillus paracasei IMC 502Increased Fecal LactobacilliBeneficial
Large
Lactobacillus paracasei IMC 502Increased Oral Persistence of Lactobacillus paracaseiNeutral
Moderate
Lactobacillus paracasei IMC 502Reduced Mutans Streptococcus CountsBeneficial
Large
Lactobacillus salivarius SD-5208Increased Lactobacilli LevelsBeneficial
Large
Lactobacillus salivarius SD-5208Increased Oral Colonization of Lactobacillus Paracasei SD1Neutral
Moderate
Lactobacillus salivarius SD-5208Reduced Mutans Streptococcus CountsBeneficial
Large

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