Effect of Probiotics on Host-Microbiota in Bacterial Infections.

2022-08-29
Pathogens (Basel, Switzerland) 11(9)
- Ascensión Rueda-Robles
- Avilene Rodríguez-Lara
- Matthew S Meyers
- María José Sáez-Lara
- Ana I Álvarez-Mercado

PubMed: 36145418
DOI: 10.3390/pathogens11090986

Study Design

Type: Review
Methods: a comprehensive review, which included the reported literature between 2016 and 2021, highlighting the clinical trials that reported the probiotics' potential to regulate gut microbiota after bacterial infection and focusing in particular on the context of antibiotic resistance and persister cells

Diseases caused by bacteria cause millions of deaths every year. In addition, the problem of resistance to antibiotics is so serious that it threatens the achievements of modern medicine. This is a very important global problem as some bacteria can also develop persistence. Indeed, the persistence of pathogenic bacteria has evolved as a potent survival strategy to overcome host organisms' defense mechanisms. Additionally, chronic or persistent infections may be caused by persisters which could facilitate antibiotic resistance. Probiotics are considered good bacteria. It has been described that the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection. Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria. Bearing in mind that current strategies to avoid bacterial persistence and prevent antibiotic resistance are not effective, other strategies need to be assessed. We have carried out a comprehensive review, which included the reported literature between 2016 and 2021, highlighting the clinical trials that reported the probiotics' potential to regulate gut microbiota after bacterial infection and focusing in particular on the context of antibiotic resistance and persister cells.

Research Insights

Lacticaseibacillus casei R0215→Modulated Gut Microbiota
the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection
Effect
Beneficial
Effect size
Moderate
Lacticaseibacillus casei R0215→Reduced Pathogen Growth
Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria.
Effect
Beneficial
Effect size
Moderate
Lactococcus lactis R1058→Modulated Gut Microbiota
the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection
Effect
Beneficial
Effect size
Moderate
Pediococcus acidilactici R1001→Improved Gut Microbiota
the modulation of gut microbiota by probiotics could have a great potential to counteract the deleterious impact and/or regulate gut microbiota after bacterial infection.
Effect
Beneficial
Effect size
Moderate
Pediococcus acidilactici R1001→Reduced Pathogen Growth
Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria.
Effect
Beneficial
Effect size
Moderate
Pediococcus acidilactici R1001→Reduced Pathogenic Bacteria Load
Probiotics might provide health benefits through the inhibition of pathogen growth or the replacement of pathogenic bacteria.
Effect
Beneficial
Effect size
Moderate