Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension.
- 2012-07-15
- Pakistan journal of biological sciences : PJBS 15(15)
- S K Verma
- Vartika Jain
- D P Singh
- PubMed: 24171260
- DOI: 10.3923/pjbs.2012.742.747
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 15
- Population
- 30 patients with stage 1 hypertension
- Methods
- Single-blind, placebo-controlled study; 3 g P. tuberosa in two divided doses vs matched placebo for twelve weeks
- Blinding
- Single-blind
- Duration
- twelve weeks
- Funding
- Unclear
The Indian Kudzu (Pueraria tuberosa DC.) is an important medicinal plant widely used in Indian and Chinese traditional systems of medicine. The present study is an attempt to evaluate effect of its tubers on blood pressure, coagulation parameters and antioxidant status in patients with stage 1 (primary) hypertension. In a long-term, single blinded, placebo controlled study; 15 patients with stage 1 hypertension (group 1), were administered 3 g P. tuberosa in two divided doses while another 15 patients (group II) were administered matched placebo for a period of twelve weeks. A significant fall of 25, 11 and 16 mmHg was observed in systolic (p < 0.001), diastolic (p < 0.05) and mean (p < 0.001) blood pressure, respectively at the end of the study. Along with blood pressure reduction, there was a significant (p < 0.01) reduction in plasma fibrinogen and significant enhancement of plasma fibrinolytic activity (p < 0.001) and serum total antioxidant status (p < 0.05). It was tolerated well without any untoward side effects.
Research Insights
significant enhancement of serum total antioxidant status
- Effect
- Beneficial
- Effect size
- Small
- Dose
- 3 g in two divided doses
A significant fall of 25, 11 and 16 mmHg was observed in systolic, diastolic and mean blood pressure, respectively at the end of the study.
- Effect
- Beneficial
- Effect size
- Large
- Dose
- 3 g in two divided doses