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Effect of Rosa damascena on improvement of adults' sleep quality: a systematic review and meta-analysis of randomized controlled trials.

  • 2021-07-31
  • Sleep medicine 87
    • Mohammad Sadegh Ghorbani Rami
    • Morteza Nasiri
    • Mohammad Sadegh Aghili Nasab
    • Zohre Jafari
    • Mahya Torkaman
    • Shahoo Feizi
    • Behnam Farahmandnia
    • Masoomeh Asadi

Study Design

Type
Meta-Analysis
Population
adults
Methods
systematic review and meta-analysis, searched databases from inception to June 30, 2021; Cochrane risk-of-bias assessment; random-effects model meta-analysis using Stata

Background

Recent studies have reported inconclusive results regarding the potential effects of Rosa damascena on sleep quality. Therefore, this review aimed to summarize the findings of parallel-group and cross-over randomized controlled trials (RCTs) on the effects of aromatherapy and oral intake of Rosa damascena on adults' sleep quality.

Methods

The electronic data sources of PubMed, Scopus, Web of Science Core Collection, Embase, CENTRAL, ProQuest, CINAHL, SID, and MagIran were searched from inception to June 30, 2021. Out of 1341 publications found in the initial search, 10 RCTs were considered eligible for this review. The Cochrane risk-of-bias assessment tool was used to evaluate the risk of bias. Sufficient data were statistically pooled by a random-effects model using Stata software (version 11.2); otherwise, a narrative summary was presented.

Results

Based on the systematic review, the inhalation and oral intake of Rosa damascena could improve some sleep-related outcomes. The pooled analysis of seven effect sizes revealed that inhalation aromatherapy with Rosa damascena significantly improved sleep quality (standardized mean difference: 2.24; 95% confidence interval: 1.01-3.48; P < 0.001). Most RCTs had fair methodological quality, and two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing.

Conclusions

The administration of Rosa damascena seems to be a promising approach in complementary and alternative medicine for the improvement of adults' sleep quality. However, considering the fair methodological quality of most RCTs and reported adverse effects, it is required to perform further high-quality RCTs to draw an evidence-based conclusion on the use of Rosa damascena for the improvement of adults' sleep quality.

Prospero no

CRD42020211778.

Research Insights

  • Rose→Improved Sleep Quality

    the pooled analysis of seven effect sizes revealed that inhalation aromatherapy with Rosa damascena significantly improved sleep quality (standardized mean difference: 2.24; 95% confidence interval: 1.01-3.48; P < 0.001).

    Effect
    Beneficial
    Effect size
    Large

Adverse Events Reported

  • Rose→frequent sneezing

    two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing.

    Finding
    Reported
  • Rose→headache

    two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing.

    Finding
    Reported
  • Rose→nausea

    two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing.

    Finding
    Reported
  • Rose→vomiting

    two RCTs reported the adverse effects of treatment, including headache, nausea, vomiting, and frequent sneezing.

    Finding
    Reported
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