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Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study.

  • 2017-07
  • Journal of Pediatric Gastroenterology and Nutrition 65(1)
    • M. C. Chua
    • K. Ben-Amor
    • C. Lay
    • A. G. E. Neo
    • Wei Chin Chiang
    • R. Rao
    • Charmaine Chew
    • S. Chaithongwongwatthana
    • N. Khemapech
    • J. Knol
    • V. Chongsrisawat


We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0.0001) until week 8 (P = 0.041), a reduction of Enterobacteriaceae from day 3/5 (P = 0.002) till week 12 (P = 0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve M-16VIncreased Fecal Acetate LevelsBeneficial
Bifidobacterium breve M-16VIncreased Proportion of Bifidobacteria in Gut MicrobiotaBeneficial
Bifidobacterium breve M-16VModulated Gut Microbiome CompositionBeneficial
Bifidobacterium breve M-16VReduced Enterobacteriaceae Levels in FecesBeneficial
Bifidobacterium breve M-16VReduced Faecal pHBeneficial

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