Effect of vitamin K2 on type 2 diabetes mellitus: A review.
- 2018-02
- Diabetes research and clinical practice 136
- Yan Li
- Jie Peng Chen
- Lili Duan
- Shuzhuang Li
- PubMed: 29196151
- DOI: 10.1016/j.diabres.2017.11.020
Study Design
- Type
- Review
- Methods
- overview of currently available studies
Type 2 diabetes mellitus (T2DM) continue to be a major public health problem around the world that frequently presents with microvascular and macrovascular complications. Individuals with T2DM are not only suffering from significant emotional and physical misery, but also at increased risk of dying from severe complications. In recent years, evidence from prospective observational studies and clinical trials has shown T2DM risk reduction with vitamin K2 supplementation. We thus did an overview of currently available studies to assess the effect of vitamin K2 supplementation on insulin sensitivity, glycaemic control and reviewed the underlying mechanisms. We proposed that vitamin K2 improved insulin sensitivity through involvement of vitamin K-dependent-protein osteocalcin, anti-inflammatory properties, and lipid-lowering effects. Vitamin K2 had a better effect than vitamin K1 on T2DM. The interpretation of this review will increase comprehension of the development of a therapeutic strategy to prevent and treat T2DM.
Research Insights
We thus did an overview of currently available studies to assess the effect of vitamin K2 supplementation on insulin sensitivity, glycaemic control
- Effect
- Beneficial
- Effect size
- Small
We proposed that vitamin K2 improved insulin sensitivity through involvement of vitamin K-dependent-protein osteocalcin, anti-inflammatory properties, and lipid-lowering effects.
- Effect
- Beneficial
- Effect size
- Small
evidence from prospective observational studies and clinical trials has shown T2DM risk reduction with vitamin K2 supplementation
- Effect
- Beneficial
- Effect size
- Small