Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial.
- 2016-02-11
- Journal of evidence-based complementary & alternative medicine 22(1)
- Maryam Mosaffa-Jahromi
- Ali-Mohammad Tamaddon
- Suleiman Afsharypuor
- Alireza Salehi
- Seyed Hassan Seradj
- Mehdi Pasalar
- Peyman Jafari
- Kamran Bagheri Lankarani
- PubMed: 26873392
- DOI: 10.1177/2156587216628374
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 120
- Population
- 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores
- Methods
- randomized double-blinded active and placebo controlled clinical trial, 3 equal groups received anise oil, Colpermin, and placebo
- Blinding
- Double-blind
- Duration
- week 4
- Large Human Trial
Depression is a prevalent disorder among patients suffering from irritable bowel syndrome. The current study was performed to evaluate the effect of a traditional Persian medicine product, anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome. In a randomized double-blinded active and placebo controlled clinical trial, 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores were categorized into 3 equal groups and received anise oil, Colpermin, and placebo. The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups. Although the mechanism is unknown yet, anise oil could be a promising choice of treatment for depressed patients with irritable bowel syndrome.
Research Insights
The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups.
- Effect
- Beneficial
- Effect size
- Small