Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

2023-09-29
Nutrients 15(19)
- Yung-Kai Lin
- Yung-Hsiang Lin
- Chi-Fu Chiang
- Li Jingling

PubMed: 37836504
DOI: 10.3390/nu15194221

Study Design

Type: Randomized Controlled Trial (RCT)
Population: Sixty-four subjects with subjective cognitive complaints
Methods: Subjects were divided into a placebo group (n = 32) and a formula-drink group (n = 32), who consumed the product for 8 weeks. Cognitive tests were administered and analyzed at weeks 0, 4, and 8.
Duration: 8 weeks

Rigorous Journal

The brain is one of the most critical organs in the human body, regulating functions such as thinking, memory, learning, and perception. Studies have indicated that fish roe, snow fungus, and yeast may have the potential to modulate cognitive, memory, and emotional functions. However, more relevant clinical research in this area still needs to be conducted. This study explored the cognition-enhancing potential of a formula beverage including fish roe, snow fungus, and yeast. Sixty-four subjects were divided into a placebo group (n = 32) and a formula-drink group (n = 32), who consumed the product for 8 weeks. Cognitive tests were administered and analyzed at weeks 0, 4, and 8. After 4 and 8 weeks, there was a significant increase in the number of memory cards, and the response times among those who consumed the formula beverage were significantly faster than those in the placebo group. The subjects remembered the old items better and were more impressed with similar items based on the week effect. There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks. In addition, there was a significant decrease in anxiety and fatigue, and improved quality of life. This formula beverage is a promising option that could be used to prevent further cognitive decline in adults with subjective cognitive complaints.

Research Insights

Tremella→Improved Delayed Memory
After 4 and 8 weeks, there was a significant increase in the number of memory cards
Effect
Beneficial
Effect size
Moderate
Tremella→Improved Emotional Processing
There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks.
Effect
Beneficial
Effect size
Moderate
Tremella→Improved Quality of Life
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate
Tremella→Improved Reaction Time
the response times among those who consumed the formula beverage were significantly faster
Effect
Beneficial
Effect size
Moderate
Tremella→Improved Recognition Memory
The subjects remembered the old items better and were more impressed with similar items based on the week effect.
Effect
Beneficial
Effect size
Moderate
Tremella→Reduced Anxiety
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate
Tremella→Reduced Fatigue
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate
yeast→Improved Delayed Memory
After 4 and 8 weeks, there was a significant increase in the number of memory cards
Effect
Beneficial
Effect size
Moderate
yeast→Improved Emotional Processing
There was a significant increase in the cue effect of happy facial expressions after the subjects consumed the formula beverage for 8 weeks.
Effect
Beneficial
Effect size
Moderate
yeast→Improved Quality of Life
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate
yeast→Improved Reaction Time
the response times among those who consumed the formula beverage were significantly faster
Effect
Beneficial
Effect size
Moderate
yeast→Improved Recognition Memory
The subjects remembered the old items better and were more impressed with similar items based on the week effect.
Effect
Beneficial
Effect size
Moderate
yeast→Reduced Anxiety
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate
yeast→Reduced Fatigue
there was a significant decrease in anxiety and fatigue, and improved quality of life.
Effect
Beneficial
Effect size
Moderate