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Effects of Bacillus Coagulans on growth performance, antioxidant capacity, immunity function, and gut health in broilers

  • 2021-06
  • Poultry Science 100(6)
    • Bing Zhang
    • Haoran Zhang
    • Yang Yu
    • Ruiqiang Zhang
    • Yan-ping Wu
    • M. Yue
    • Caimei Yang

Abstract

This study evaluated the effects of Bacillus coagulans (B. coagulans) as an alternative to antibiotics on growth performance, antioxidant capacity, immunity function and gut health in broilers. A total of 480 one-day-old broilers were randomly divided into 3 treatments with 8 replicates comprising 20 broilers each. The experiment lasted 42 d. Treatments included: basal diet without antibiotics (NCO); basal diet supplemented with 75 mg/kg chlortetracycline (ANT); basal diet supplemented with 5 × 109 CFU/kg B. coagulans(BC). The B. coagulans enhanced body weight (BW) and average daily gain compared with the NCO group (P < 0.05). However, there were no significant differences in average daily feed intake and feed: gain ratio (F: G) among three groups (P > 0.05). The B. coagulans significantly increased catalase, superoxide dismutase, and glutathione peroxidase levels and reduced malondialdehyde levels (P < 0.05). The serum immunoglobulins (IgA, IgM, and IgY) were significantly higher in the BC group when compared to the NCO and ANT groups (P < 0.05). The B. coagulans also markedly reduced serum levels of proinflammatory factors (IL-1β, IL-6, and TNF-α) and enhanced anti-inflammatory factor (IL-10) concentrations compared with control group (P < 0.05). Moreover, compared with the control group, BC significantly inhibited serum xanthine oxidase activity (P < 0.05). The levels of acetic acid, propionic acid, butyrate, isobutyric acid and valerate in BC group were significantly increased on d 42 compared with the NCO and ANT groups (P < 0.05). Furthermore, BC significantly altered cecal microbiota by reducing Desulfovibrio and Parasutterella, and by increasing Alistipes and Odoribacter (P < 0.05, P < 0.05, P < 0.001, P < 0.01, respectively). In conclusion, dietary B. coagulans, when used as an alternative to antibiotics, improved body weight, average daily gain, antioxidant capacity, immunity function and gut health in broilers.

Keywords: broiler, Bacillus coagulans; growth performance; gut health; immunity function.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus coagulansEnhanced Immune FunctionBeneficial
Large
Bacillus coagulansImproved Antioxidant CapacityBeneficial
Large
Bacillus coagulansImproved Gut HealthBeneficial
Large
Bacillus coagulans LactoSpore 1 billion CFUEnhanced Immune FunctionBeneficial
Large
Bacillus coagulans LactoSpore 1 billion CFUImproved Antioxidant CapacityBeneficial
Large
Bacillus coagulans LactoSpore 1 billion CFUImproved Growth PerformanceBeneficial
Moderate
Bacillus coagulans LactoSpore 1 billion CFUImproved Gut HealthBeneficial
Large
Bacillus coagulans LactoSpore 1 billion CFUReduced Inflammation LevelsBeneficial
Large
Bacillus coagulans MTCC 5856Altered Gut Microbiota CompositionBeneficial
Large
Bacillus coagulans MTCC 5856Enhanced Antioxidant Enzyme ActivityBeneficial
Moderate
Bacillus coagulans MTCC 5856Enhanced Immune FunctionBeneficial
Large
Bacillus coagulans MTCC 5856Improved Antioxidant CapacityBeneficial
Large
Bacillus coagulans MTCC 5856Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bacillus coagulans MTCC 5856Reduced Inflammation LevelsBeneficial
Large
Bacillus coagulans ProDuraEnhanced Immune FunctionBeneficial
Large
Bacillus coagulans ProDuraImproved Antioxidant CapacityBeneficial
Large
Bacillus coagulans ProDuraImproved Gut HealthBeneficial
Large
Bacillus coagulans ProDuraReduced Proinflammatory SignalingBeneficial
Large
Bacillus coagulans ProDuraReduced Serum Xanthine Oxidase ActivityBeneficial
Large
Bacillus coagulans SC208Improved Antioxidant CapacityBeneficial
Large
Bacillus coagulans SC208Improved Growth PerformanceBeneficial
Moderate
Bacillus coagulans SC208Improved Gut HealthBeneficial
Large
Bacillus coagulans SC208Improved Immune FunctionBeneficial
Large
Bacillus coagulans SC208Reduced Inflammatory ResponseBeneficial
Large
Bacillus coagulans SNZ-1969Altered Gut Microbiota CompositionBeneficial
Large
Bacillus coagulans SNZ-1969Improved Antioxidant CapacityBeneficial
Large
Bacillus coagulans SNZ-1969Improved Body WeightBeneficial
Moderate
Bacillus coagulans SNZ-1969Improved Immune FunctionBeneficial
Large
Bacillus coagulans SNZ-1969Increased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Bacillus coagulans SNZ-1969Reduced Proinflammatory SignalingBeneficial
Large
Bacillus coagulans SNZ-1969Reduced Serum Xanthine Oxidase ActivityBeneficial
Large
Bacillus coagulans Unique IS-2Improved Antioxidant CapacityBeneficial
Large
Bacillus coagulans Unique IS-2Improved Growth PerformanceBeneficial
Moderate
Bacillus coagulans Unique IS-2Improved Gut HealthBeneficial
Large
Bacillus coagulans Unique IS-2Improved Immune FunctionBeneficial
Large
Bacillus coagulans Unique IS-2Reduced Inflammation LevelsBeneficial
Large
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