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Abstract

Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinical study was performed on 69 preterm infants (<37 gestation wk). Weight gain was defined as the primary outcome measure. In antibiotic-treated infants, probiotic supplementation resulted in a higher body weight compared with placebo (p < 0.001). In the probiotic group, the fecal pH was significantly lower than in the placebo group. The fecal concentrations of acetate and lactate were 42 and 38% higher, respectively, in the probiotic group than in the placebo group. Fecal calprotectin was lower in the probiotic group (p = 0.041), while fecal IgA was higher in this group compared with the placebo group (p = 0.021).

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium bifidum/lactis Bb-02Elevated Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Body WeightBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Increased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium bifidum/lactis Bb-02Reduced Faecal CalprotectinBeneficial
Small
Bifidobacterium bifidum/lactis Bb-02Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactisElevated Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium lactisIncreased Body WeightBeneficial
Large
Bifidobacterium lactisIncreased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium lactisIncreased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium lactisReduced Faecal pHBeneficial
Moderate
Bifidobacterium lactisReduced Fecal CalprotectinBeneficial
Small
Bifidobacterium lactis B420Increased Body WeightBeneficial
Large
Bifidobacterium lactis B420Increased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium lactis B420Increased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium lactis B420Increased Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium lactis B420Reduced Faecal CalprotectinBeneficial
Small
Bifidobacterium lactis B420Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis Bb-02Increased Body WeightBeneficial
Large
Bifidobacterium lactis Bb-02Increased Fecal Acetate ConcentrationBeneficial
Moderate
Bifidobacterium lactis Bb-02Increased Fecal IgA ConcentrationBeneficial
Small
Bifidobacterium lactis Bb-02Increased Fecal Lactate ConcentrationBeneficial
Moderate
Bifidobacterium lactis Bb-02Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis Bb-02Reduced Fecal Calprotectin LevelsBeneficial
Small
Bifidobacterium lactis BI-04Elevated Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium lactis BI-04Increased Body WeightBeneficial
Large
Bifidobacterium lactis BI-04Increased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium lactis BI-04Increased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium lactis BI-04Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis BI-04Reduced Fecal CalprotectinBeneficial
Small
Bifidobacterium lactis BL818Elevated Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium lactis BL818Increased Body WeightBeneficial
Large
Bifidobacterium lactis BL818Increased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium lactis BL818Increased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium lactis BL818Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Fecal CalprotectinBeneficial
Small
Bifidobacterium lactis BLA80Elevated Fecal Lactate LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Body WeightBeneficial
Large
Bifidobacterium lactis BLA80Increased Fecal Acetate LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Fecal Immunoglobulin A LevelsBeneficial
Small
Bifidobacterium lactis BLA80Reduced Faecal CalprotectinBeneficial
Small
Bifidobacterium lactis BLA80Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Increased Body WeightBeneficial
Large
Bifidobacterium lactis HDS Bb-02Increased Fecal Acetate ConcentrationBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Increased Fecal Secretory IgA LevelsBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Increased Lactate LevelsBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Reduced Faecal pHBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Reduced Fecal CalprotectinBeneficial
Small
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