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Effects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: a Double-Blind, Placebo-Controlled, Randomized Study

  • 2006-11
  • Journal of Clinical Microbiology 44(11)
    • R. Mohan
    • C. Koebnick
    • J. Schildt
    • S. Schmidt
    • M. Mueller
    • M. Possner
    • M. Radke
    • M. Blaut

Abstract

The gastrointestinal microbiota of preterm infants in a neonatal intensive care unit differs from that of term infants. In particular, the colonization of preterm infants by bifidobacteria is delayed. A double-blind, placebo-controlled, randomized clinical study was performed on 69 preterm infants to investigate the role of Bifidobacterium lactis Bb12 supplementation in modifying the gut microbiota. Both culture-dependent and culture-independent approaches were used to study the gut microbiota. Bifidobacterial numbers, determined by fluorescence in situ hybridization, were significantly higher in the probiotic than in the placebo group (log(10) values per g of fecal wet weight: probiotic, 8.18 + 0.54 [standard error of the mean]; placebo, 4.82 + 0.51; P < 0.001). A similar trend for bifidobacterial numbers was also obtained with the culture-dependent method. The infants supplemented with Bb12 also had lower viable counts of Enterobacteriaceae (log(10) values of CFU per g of fecal wet weight: probiotic, 7.80 + 0.34; placebo, 9.03 + 0.35; P = 0.015) and Clostridium spp. (probiotic, 4.89 + 0.30; placebo, 5.99 + 0.32; P = 0.014) than the infants in the placebo group. Supplementation of B. lactis Bb12 did not reduce the colonization by antibiotic-resistant organisms in the study population. However, the probiotic supplementation increased the cell counts of bifidobacteria and reduced the cell counts of enterobacteria and clostridia.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium bifidum BB-06Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium bifidum BB-06Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium bifidum BB-06Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Bifidobacterial PopulationBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium bifidum/lactis Bb-02Reduced Clostridium Species NumbersBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactisIncreased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactisReduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactisReduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis Bb-02Increased Bifidobacterial Cell CountsBeneficial
Large
Bifidobacterium lactis Bb-02No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis Bb-02Reduced Clostridium Species CountsBeneficial
Moderate
Bifidobacterium lactis Bb-02Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis BB-12Increased Bifidobacteria in ColonBeneficial
Large
Bifidobacterium lactis BB-12No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis BB-12Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis BB-12Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis Bi-07Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis Bi-07No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis Bi-07Reduced Clostridia CountsBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis BL818Increased Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis BL818Reduced Clostridium Species CountsBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Bifidobacterial PopulationBeneficial
Large
Bifidobacterium lactis BLA80No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis BLA80Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis BLC-1Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis BLC-1No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis BLC-1Reduced Clostridia CountsBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis HA-194Increased Bifidobacterial PopulationBeneficial
Large
Bifidobacterium lactis HA-194No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis HA-194Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis HA-194Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Increased Bifidobacterial PopulationBeneficial
Large
Bifidobacterium lactis HDS Bb-02No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis HDS Bb-02Reduced Clostridia CountsBeneficial
Moderate
Bifidobacterium lactis HDS Bb-02Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Bifidobacteria LevelsBeneficial
Large
Bifidobacterium lactis ISS BifReduced Clostridium Species CountsBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Enterobacteriaceae Viable CountsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Bifidobacterial CountsBeneficial
Large
Bifidobacterium lactis MAK16B42LReduced Clostridium Species CountsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Enterobacterial CountsBeneficial
Moderate
Bifidobacterium lactis R101-8Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis R101-8No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis R101-8Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis SD-5219Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis SD-5219Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis UABla-12Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis UABla-12No Reduction in Antibiotic-Resistant Organism ColonizationNeutral
Small
Bifidobacterium lactis UABla-12Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium lactis VK2Increased Gut BifidobacteriaBeneficial
Large
Bifidobacterium lactis VK2Reduced Clostridium CountsBeneficial
Moderate
Bifidobacterium lactis VK2Reduced Enterobacteriaceae CountsBeneficial
Moderate
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