Effects of Bifidobacterium longum BB536 on lipid profile and histopathological changes in hypercholesterolaemic rats.
- 2015-10-15
- Beneficial Microbes 6(5)
- S. H. Al-Sheraji
- I. Amin
- A. Azlan
- M. Y. Manap
- F. Hassan
- PubMed: 26065647
- DOI: 10.3920/BM2014.0032
Abstract
The present study investigated the effects of Bifidobacterium longum BB536 on lipid profile, liver and kidney function, and body fat in hypercholesterolaemic rats. 40 Sprague-Dawley rats were randomly divided into five groups. The negative control group received a standard diet. The positive control group received a cholesterol-enriched diet, whereas the intervention groups received a cholesterol-enriched diet supplemented with B. longum BB536 alone or in combination with inulin or Mangifera pajang fibrous polysaccharides. After 8 weeks, plasma lipids, and liver and kidney function were tested. Intake of the cholesterol-enriched diet increased total cholesterol, alanine aminotransferase, gamma-glutamyl transferase, creatinine, urea, liver weight, adipose tissue weight, liver lipid deposition and adipocyte size. B. longum BB536 supplementation significantly reduced total cholesterol, liver lipid deposition and adipocyte size, and positively affected liver and kidney function. These effects were significantly increased in the presence of inulin and M. pajang fibrous polysaccharides.
Keywords: bifidobacteria; histology; hypocholesterolaemic rats; lipid profile.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium longum B1-05 | Improved Kidney Function | Beneficial | Large |
| Bifidobacterium longum B1-05 | Improved Liver Function | Beneficial | Large |
| Bifidobacterium longum B1-05 | Improved Liver Lipid Deposition | Beneficial | Moderate |
| Bifidobacterium longum B1-05 | Reduced Adipocyte Size | Beneficial | Large |
| Bifidobacterium longum B1-05 | Reduced Total Cholesterol Levels | Beneficial | Large |
| Bifidobacterium longum BB536 | Improved Kidney Function | Beneficial | Large |
| Bifidobacterium longum BB536 | Improved Liver Function | Beneficial | Large |
| Bifidobacterium longum BB536 | Reduced Adipocyte Size | Beneficial | Large |
| Bifidobacterium longum BB536 | Reduced Liver Fat Deposition | Beneficial | Large |
| Bifidobacterium longum BB536 | Reduced Total Cholesterol Levels | Beneficial | Large |
| Bifidobacterium longum SP54 | Improved Kidney Function | Beneficial | Large |
| Bifidobacterium longum SP54 | Improved Liver Function | Beneficial | Large |
| Bifidobacterium longum SP54 | Reduced Adipocyte Size | Beneficial | Large |
| Bifidobacterium longum SP54 | Reduced Liver Fat Deposition | Beneficial | Large |
| Bifidobacterium longum SP54 | Reduced Total Cholesterol Levels | Beneficial | Large |