Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial

2018-09-24
Journal of Clinical Periodontology 45(10)
- M. Invernici
- S. Salvador
- P. Silva
- M. M. Soares
- R. Casarin
- D. Palioto
- S. Souza
- M. Taba
- A. B. Novaes
- F. Furlaneto
- M. Messora

PubMed: 30076613
DOI: 10.1111/jcpe.12995

Abstract

Aim: This randomized placebo-controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019-containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.

Materials and methods: Forty-one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.

Results: The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.

Conclusion: The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).

Keywords: Bifidobacterium lactis; periodontitis; probiotics; root planing.

Research Insights

Supplement	Health Outcome	Effect Type	Effect Size
Bifidobacterium animalis subsp. lactis HN019	Improved Clinical Attachment	Beneficial	Large
Bifidobacterium animalis subsp. lactis HN019	Reduced Periodontal Pathogens	Beneficial	Large
Bifidobacterium animalis subsp. lactis HN019	Reduced Probing Depth	Beneficial	Large
Bifidobacterium animalis subsp. lactis HN019	Reduced Proinflammatory Cytokine Levels	Beneficial	Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94	Improved Clinical Attachment	Beneficial	Large
Bifidobacterium animalis subsp. lactis LAFTI B94	Increased Subgingival Biofilm B. lactis HN019 DNA Levels	Beneficial	Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94	Reduced Periodontal Pathogens	Beneficial	Large
Bifidobacterium animalis subsp. lactis LAFTI B94	Reduced Probing Depths	Beneficial	Large
Bifidobacterium animalis subsp. lactis LAFTI B94	Reduced Proinflammatory Cytokine Levels	Beneficial	Moderate
Bifidobacterium lactis BS01	Improved Clinical Attachment	Beneficial	Large
Bifidobacterium lactis BS01	Increased Subgingival Biofilm B. lactis HN019 DNA Levels	Beneficial	Moderate
Bifidobacterium lactis BS01	Reduced Periodontal Pathogen Burden	Beneficial	Moderate
Bifidobacterium lactis BS01	Reduced Probing Depth	Beneficial	Large
Bifidobacterium lactis BS01	Reduced Proinflammatory Cytokine Levels	Beneficial	Moderate
Bifidobacterium lactis HN019	Improved Clinical Attachment	Beneficial	Large
Bifidobacterium lactis HN019	Increased Subgingival Biofilm B. lactis HN019 DNA Levels	Beneficial	Moderate
Bifidobacterium lactis HN019	Reduced Periodontal Pathogens	Beneficial	Large
Bifidobacterium lactis HN019	Reduced Probing Depth	Beneficial	Large
Bifidobacterium lactis HN019	Reduced Proinflammatory Cytokine Levels	Beneficial	Moderate
Bifidobacterium lactis SD-5219	Improved Clinical Attachment	Beneficial	Large
Bifidobacterium lactis SD-5219	Increased B. lactis HN019 DNA Copies	Neutral	Small
Bifidobacterium lactis SD-5219	Reduced Periodontal Pathogens	Beneficial	Large
Bifidobacterium lactis SD-5219	Reduced Probing Depths	Beneficial	Large
Bifidobacterium lactis SD-5219	Reduced Pro-Inflammatory Cytokines	Beneficial	Moderate