Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial
- 2018-09-24
- Journal of Clinical Periodontology 45(10)
- M. Invernici
- S. Salvador
- P. Silva
- M. M. Soares
- R. Casarin
- D. Palioto
- S. Souza
- M. Taba
- A. B. Novaes
- F. Furlaneto
- M. Messora
- PubMed: 30076613
- DOI: 10.1111/jcpe.12995
Abstract
Aim: This randomized placebo-controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019-containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.
Materials and methods: Forty-one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.
Results: The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.
Conclusion: The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).
Keywords: Bifidobacterium lactis; periodontitis; probiotics; root planing.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis subsp. lactis HN019 | Improved Clinical Attachment | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Periodontal Pathogens | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Probing Depth | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Proinflammatory Cytokine Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Improved Clinical Attachment | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Increased Subgingival Biofilm B. lactis HN019 DNA Levels | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Periodontal Pathogens | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Probing Depths | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Proinflammatory Cytokine Levels | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Improved Clinical Attachment | Beneficial | Large |
| Bifidobacterium lactis BS01 | Increased Subgingival Biofilm B. lactis HN019 DNA Levels | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Periodontal Pathogen Burden | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Probing Depth | Beneficial | Large |
| Bifidobacterium lactis BS01 | Reduced Proinflammatory Cytokine Levels | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Improved Clinical Attachment | Beneficial | Large |
| Bifidobacterium lactis HN019 | Increased Subgingival Biofilm B. lactis HN019 DNA Levels | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Reduced Periodontal Pathogens | Beneficial | Large |
| Bifidobacterium lactis HN019 | Reduced Probing Depth | Beneficial | Large |
| Bifidobacterium lactis HN019 | Reduced Proinflammatory Cytokine Levels | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Improved Clinical Attachment | Beneficial | Large |
| Bifidobacterium lactis SD-5219 | Increased B. lactis HN019 DNA Copies | Neutral | Small |
| Bifidobacterium lactis SD-5219 | Reduced Periodontal Pathogens | Beneficial | Large |
| Bifidobacterium lactis SD-5219 | Reduced Pro-Inflammatory Cytokines | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Probing Depths | Beneficial | Large |