Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial
- 2018-09-27
- International Journal of Obesity 43(9)
- A. Pedret
- R. Valls
- L. Calderón-Pérez
- E. Llauradó
- J. Companys
- L. Pla-Pagà
- A. Moragas
- F. Martín-Luján
- Y. Ortega
- M. Giralt
- A. Caimari
- E. Chenoll
- S. Genovés
- P. Martorell
- F. Codoñer
- D. Ramón
- L. Arola
- R. Solà
- PubMed: 30262813
- DOI: 10.1038/s41366-018-0220-0
Abstract
Background: The effects of probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) and those of its heat-killed form (h-k Ba8145) on human anthropometric adiposity biomarkers are unknown.
Objective: To assess the effect of Ba8145 and h-k Ba8145 ingestion on anthropometric adiposity biomarkers.
Design: Randomized, parallel, double-blind, placebo-controlled trial with abdominally obese individuals. Participants (n = 135) consumed 1 capsule/day containing 1010 colony forming unit (CFU) of Ba8145, 1010 CFU of h-k Ba8145, or placebo (maltodextrin) for 3 months.
Results: Ba8145 ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index (P < 0.05) versus its baseline. Changes versus the placebo group reached significance (P < 0.05) after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group (P < 0.05). The decrease in visceral fat area after Ba8145 treatments reached significance (P < 0.05) only after h-k Ba8145. When analyses by gender were performed, significance remained only for women. Diastolic blood pressure and HOMA index decreased (P < 0.05) after h-k Ba8145. Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight (P = 0.003).
Conclusions: In abdominally obese individuals, consumption of Ba8145, both as viable and mainly as heat-killed cells, improves anthropometric adiposity biomarkers, particularly in women. An increase in the gut Akkermansia genus appears as a possible mechanism involved. Our results support Ba8145 probiotic as a complementary strategy in obesity management.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium animalis | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis B420 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced HOMA Index | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Visceral Fat Area | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis BS-01 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis LAFTI B94 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium animalis subsp. lactis VK2 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis | Improved HOMA Index | Beneficial | Small |
| Bifidobacterium lactis | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis B420 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis B420 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis BI-04 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis BI-04 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Reduced Waist-to-Height Ratio | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis Bi-07 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis Bl-04 | Reduced HOMA Index | Beneficial | Small |
| Bifidobacterium lactis Bl-04 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis Bl-04 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis BL818 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis BL818 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis BLA80 | Reduced Visceral Fat Area | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis BLC-1 | Reduced HOMA Index | Beneficial | Small |
| Bifidobacterium lactis BLC-1 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Improved HOMA Index | Beneficial | Small |
| Bifidobacterium lactis BS01 | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis BS01 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis DSM 15954 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis DSM 15954 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis DSM 15954 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis ISS Bif | Reduced HOMA Index | Beneficial | Small |
| Bifidobacterium lactis ISS Bif | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis/longum | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis/longum | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Reduced Waist-to-Height Ratio | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis MAK16B42L | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Reduced Waist-to-Height Ratio | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Improved Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis R101-8 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Increased Gut Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis SD-5219 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis SD-5219 | Reduced Waist Circumference | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Improved HOMA Index | Beneficial | Small |
| Bifidobacterium lactis UABla-12 | Increased Abundance of Akkermansia Species | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Body Mass Index | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Bifidobacterium lactis UABla-12 | Reduced Visceral Fat | Beneficial | Small |
| Bifidobacterium lactis UABla-12 | Reduced Waist Circumference | Beneficial | Moderate |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Reduced Body Mass Index | Beneficial | Moderate |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Reduced Diastolic Blood Pressure | Beneficial | Small |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Reduced Visceral Fat Mass | Beneficial | Moderate |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Reduced Waist Circumference | Beneficial | Moderate |
| Heat-treated Bifidobacterium animalis subsp. lactis BPL1 | Reduced Waist-to-Height Ratio | Beneficial | Moderate |