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Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

  • 2018-09-27
  • International Journal of Obesity 43(9)
    • A. Pedret
    • R. Valls
    • L. Calderón-Pérez
    • E. Llauradó
    • J. Companys
    • L. Pla-Pagà
    • A. Moragas
    • F. Martín-Luján
    • Y. Ortega
    • M. Giralt
    • A. Caimari
    • E. Chenoll
    • S. Genovés
    • P. Martorell
    • F. Codoñer
    • D. Ramón
    • L. Arola
    • R. Solà

Abstract

Background: The effects of probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) and those of its heat-killed form (h-k Ba8145) on human anthropometric adiposity biomarkers are unknown.

Objective: To assess the effect of Ba8145 and h-k Ba8145 ingestion on anthropometric adiposity biomarkers.

Design: Randomized, parallel, double-blind, placebo-controlled trial with abdominally obese individuals. Participants (n = 135) consumed 1 capsule/day containing 1010 colony forming unit (CFU) of Ba8145, 1010 CFU of h-k Ba8145, or placebo (maltodextrin) for 3 months.

Results: Ba8145 ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index (P < 0.05) versus its baseline. Changes versus the placebo group reached significance (P < 0.05) after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group (P < 0.05). The decrease in visceral fat area after Ba8145 treatments reached significance (P < 0.05) only after h-k Ba8145. When analyses by gender were performed, significance remained only for women. Diastolic blood pressure and HOMA index decreased (P < 0.05) after h-k Ba8145. Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight (P = 0.003).

Conclusions: In abdominally obese individuals, consumption of Ba8145, both as viable and mainly as heat-killed cells, improves anthropometric adiposity biomarkers, particularly in women. An increase in the gut Akkermansia genus appears as a possible mechanism involved. Our results support Ba8145 probiotic as a complementary strategy in obesity management.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
BifidobacteriumImproved Insulin SensitivityBeneficial
Moderate
BifidobacteriumIncreased Abundance of Akkermansia SpeciesBeneficial
Moderate
BifidobacteriumReduced Body Mass IndexBeneficial
Moderate
BifidobacteriumReduced Diastolic Blood PressureBeneficial
Small
BifidobacteriumReduced Visceral Fat MassBeneficial
Moderate
BifidobacteriumReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalisImproved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalisIncreased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalisReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalisReduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalisReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium animalisReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactisImproved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactisReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis B420Reduced Visceral FatBeneficial
Small
Bifidobacterium animalis subsp. lactis B420Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis BLC1Reduced HOMA IndexBeneficial
Small
Bifidobacterium animalis subsp. lactis BLC1Reduced Visceral Fat AreaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis BS-01Reduced Visceral FatBeneficial
Small
Bifidobacterium animalis subsp. lactis BS-01Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Visceral FatBeneficial
Small
Bifidobacterium animalis subsp. lactis CECT 8145Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Increased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis HN019Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Visceral FatBeneficial
Small
Bifidobacterium animalis subsp. lactis LAFTI B94Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium animalis subsp. lactis VK2Reduced Visceral FatBeneficial
Small
Bifidobacterium animalis subsp. lactis VK2Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactisImproved HOMA IndexBeneficial
Small
Bifidobacterium lactisIncreased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactisReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactisReduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactisReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactisReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis B420Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis B420Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis B420Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis B420Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis B420Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BI-04Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis BI-04Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis BI-04Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BI-04Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis BI-04Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis BI-04Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BI-04Reduced Waist-to-Height RatioBeneficial
Moderate
Bifidobacterium lactis Bi-07Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis Bi-07Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis Bi-07Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis Bi-07Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis Bl-04Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis Bl-04Reduced HOMA IndexBeneficial
Small
Bifidobacterium lactis Bl-04Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis Bl-04Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BL818Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis BL818Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BL818Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis BL818Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis BL818Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis BLA80Reduced Visceral Fat AreaBeneficial
Moderate
Bifidobacterium lactis BLA80Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis BLC-1Reduced HOMA IndexBeneficial
Small
Bifidobacterium lactis BLC-1Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis BLC-1Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis BS01Improved HOMA IndexBeneficial
Small
Bifidobacterium lactis BS01Increased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis BS01Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis BS01Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis DSM 15954Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis DSM 15954Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis DSM 15954Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis DSM 15954Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis DSM 15954Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis ISS BifReduced HOMA IndexBeneficial
Small
Bifidobacterium lactis ISS BifReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis ISS BifReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis/longumImproved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis/longumIncreased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis/longumReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis/longumReduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis/longumReduced Visceral FatBeneficial
Small
Bifidobacterium lactis/longumReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis/longumReduced Waist-to-Height RatioBeneficial
Moderate
Bifidobacterium lactis MAK16B42LImproved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis MAK16B42LReduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis MAK16B42LReduced Waist-to-Height RatioBeneficial
Moderate
Bifidobacterium lactis R101-8Improved Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis R101-8Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis R101-8Increased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis R101-8Reduced Visceral Fat MassBeneficial
Moderate
Bifidobacterium lactis R101-8Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis SD-5219Improved Insulin SensitivityBeneficial
Moderate
Bifidobacterium lactis SD-5219Increased Gut Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis SD-5219Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis SD-5219Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis SD-5219Reduced Waist CircumferenceBeneficial
Moderate
Bifidobacterium lactis UABla-12Improved HOMA IndexBeneficial
Small
Bifidobacterium lactis UABla-12Increased Abundance of Akkermansia SpeciesBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Body Mass IndexBeneficial
Moderate
Bifidobacterium lactis UABla-12Reduced Diastolic Blood PressureBeneficial
Small
Bifidobacterium lactis UABla-12Reduced Visceral FatBeneficial
Small
Bifidobacterium lactis UABla-12Reduced Waist CircumferenceBeneficial
Moderate
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Improved Insulin SensitivityBeneficial
Moderate
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Body Mass IndexBeneficial
Moderate
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Diastolic Blood PressureBeneficial
Small
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Visceral Fat MassBeneficial
Moderate
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Waist CircumferenceBeneficial
Moderate
Heat-treated Bifidobacterium animalis subsp. lactis BPL1Reduced Waist-to-Height RatioBeneficial
Moderate

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