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Effects of Dietary Supplementation of Lactobacillus delbrueckii on Gut Microbiome and Intestinal Morphology in Weaned Piglets

  • 2021-08-19
  • Frontiers in Veterinary Science 8
    • Xiao-Long Wang
    • Zhu-Ying Liu
    • Yinghui Li
    • Lingyuan Yang
    • J. Yin
    • Jianhua He
    • D. Hou
    • Ya-Li Liu
    • Xingguo Huang

Abstract

Lactobacillus delbrueckii is a Gram-positive bacterium mostly used in the dairy industry for yogurt and cheese. The present study was designed to evaluate the effects of Lactobacillus delbrueckii on serum biochemical parameters, intestinal morphology, and performance by supplementing at a dietary level of 0.1% in diets for weaned piglets. Eighty healthy weaned piglets (initial body weight: 7.56 ± 0.2 kg) were randomly divided into two feeding groups with four replicates in each group (n = 10 animals per replicate); piglets were fed with basal diet (CON) or basal diet containing 0.1% Lactobacillus delbrueckii (LAC). The results showed that dietary supplementation of Lactobacillus delbrueckii improved growth performance and increased serum HDL and insulin levels in piglets on the 28th day of the experimental time (p < 0.05). The gut microbe analysis revealed that Lactobacillus delbrueckii significantly decreased the relative abundance of the phyla Bacteroidetes, but increased the relative abundance of the phyla Firmicutes. The Lactobacillus delbrueckii also significantly increased the relative abundance of Bifidobacterium and Lactobacillus at the genus level of the bacterial community in the ileum, but decreased the relative abundance of unclassified Clostridiales. Moreover, Lactobacillus delbrueckii improved mucosal morphology by obtaining higher intestinal villus height (p < 0.05), significantly increasing the concentrations of butyrate, isobutyric acid, and isovaleric acid in colonic chyme of piglets, but decreasing the intestinal pH at the duodenum and ileum on the 28th day of the experimental time. In conclusion, dietary supplementation of Lactobacillus delbrueckii in the diet of weaned piglets can improve intestinal morphology and modulate the microbiota community to promote growth performance.

Keywords: Lactobacillus delbrueckii; gut microbes; mucosal morphology; short chain fatty acids; weaned piglets.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus delbrueckiiDecreased Relative Abundance of Unclassified ClostridialesNeutral
Small
Lactobacillus delbrueckiiElevated Insulin LevelsBeneficial
Moderate
Lactobacillus delbrueckiiImproved Growth PerformanceBeneficial
Moderate
Lactobacillus delbrueckiiImproved HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus delbrueckiiImproved Intestinal Villus HeightBeneficial
Large
Lactobacillus delbrueckiiIncreased Abundance of FirmicutesBeneficial
Moderate
Lactobacillus delbrueckiiIncreased Fecal LactobacilliBeneficial
Moderate
Lactobacillus delbrueckiiIncreased Gut BifidobacteriaBeneficial
Moderate
Lactobacillus delbrueckiiReduced Bacteroidetes AbundanceNeutral
Small
Lactobacillus delbrueckii VPro 315Elevated Insulin LevelsBeneficial
Moderate
Lactobacillus delbrueckii VPro 315Improved HDL Cholesterol LevelsBeneficial
Moderate
Lactobacillus delbrueckii VPro 315Improved Intestinal Villus HeightBeneficial
Large
Lactobacillus delbrueckii VPro 315Increased Abundance of FirmicutesBeneficial
Moderate

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