Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomized Controlled Trial.

2022-12-08
Nutrients 14(24)
- Ji Soo Baik
- Ji Hong Min
- Sung Min Ju
- Jae Hyun Ahn
- Sung Hwa Ko
- Hyun Soo Chon
- Min Sun Kim
- Yong Il Shin

PubMed: 36558397
DOI: 10.3390/nu14245238

Study Design

Type: Randomized Controlled Trial (RCT)
Population: Thirty healthy adults were divided into FGE and placebo groups to compare BP and velocity of the CCA and ICA; and Twenty-eight healthy adults were divided into FGE and placebo groups to compare rCBF and PBF
Methods: The study was divided into two parts: (1) Thirty healthy adults were divided into FGE and placebo groups to compare BP and velocity of the CCA and ICA; and (2) Twenty-eight healthy adults were divided into FGE and placebo groups to compare rCBF and PBF and determine changes before/after ingestion

Rigorous Journal

Aged or fermented garlic extract (FGE) is a natural remedy that improves vascular function through increasing vascular nitric oxide (NO) bioavailability. This is because nitrite (NO₂^-), a NO metabolite, can be produced through bioconversion with macrobacteria during the fermentation of foods like garlic. We aimed to evaluate the effects of NO₂^- in FGE on blood flow (BF), blood pressure (BP), velocity of the common carotid artery (CCA) and internal carotid artery (ICA), regional cerebral BF (rCBF), and peripheral BF (PBF). The study was divided into two parts: (1) Thirty healthy adults were divided into FGE and placebo groups to compare BP and velocity of the CCA and ICA; and (2) Twenty-eight healthy adults were divided into FGE and placebo groups to compare rCBF and PBF and determine changes before/after ingestion. Significant changes were noted in BP and the velocity of both CCA 30-60 min after FGE ingestion. FGE ingestion resulted in significant increases in rCBF and increases in body surface temperature through alterations in PBF. No detectable clinical side effects were noted. Overall, oral administration of NO₂^- containing FGE demonstrated acute positive effects in upregulating BF, including the CCA, BP, rCBF, and PBF. Follow-up studies with larger sample sizes and long-term ingestion may be needed.

Research Insights

black garlic→Increased Body Surface Temperature
FGE ingestion resulted in significant increases in rCBF and increases in body surface temperature through alterations in PBF.
Effect
Beneficial
Effect size
Small
black garlic→Increased Common Carotid Artery Velocity
Significant changes were noted in BP and the velocity of both CCA 30-60 min after FGE ingestion.
Effect
Beneficial
Effect size
Small
black garlic→Increased Internal Carotid Artery Velocity
The study was divided into two parts: (1) Thirty healthy adults were divided into FGE and placebo groups to compare BP and velocity of the CCA and ICA
Effect
Neutral
Effect size
Small
black garlic→Increased Peripheral Blood Flow
FGE ingestion resulted in significant increases in rCBF and increases in body surface temperature through alterations in PBF.
Effect
Beneficial
Effect size
Small
black garlic→Increased Regional Cerebral Blood Flow
FGE ingestion resulted in significant increases in rCBF and increases in body surface temperature through alterations in PBF.
Effect
Beneficial
Effect size
Small
black garlic→Reduced Blood Pressure
Significant changes were noted in BP and the velocity of both CCA 30-60 min after FGE ingestion.
Effect
Beneficial
Effect size
Small

Adverse Events Reported

black garlic→Overall tolerability
No detectable clinical side effects were noted.
Finding
Reported