Effects of heat-killed Lactiplantibacillus plantarum TWK10 on exercise performance, fatigue, and muscle growth in healthy male adults.
- 2023-10
- Physiological reports 11(19)
- Yi-Chen Cheng
- Chia-Chia Lee
- Mon-Chien Lee
- Han-Yin Hsu
- Jin-Seng Lin
- Chi-Chang Huang
- Koichi Watanabe
- PubMed: 37816697
- DOI: 10.14814/phy2.15835
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Population
- 30 healthy males aged 20-40 years
- Methods
- Double-blind, placebo-controlled clinical trial, 6 weeks of heat-killed TWK10 administration
- Blinding
- Double-blind
- Duration
- 6 weeks
- Funding
- Unclear
Consumption of Lactiplantibacillus plantarum TWK10 (TWK10) has beneficial probiotic effects, improves exercise endurance performance, regulates body composition, and mitigates aging-related problems in mice and humans. Here, we investigated the effects of heat-killed TWK10 on exercise endurance performance, muscle weight and strength, fatigue, and body composition in a double-blind, placebo-controlled clinical trial. Thirty healthy males aged 20-40 years were assigned to the Control group or heat-killed TWK10 group (TWK10-HK) in a balanced order according to each individual's initial maximal oxygen uptake. After 6-week administration, the exercise endurance time in the TWK10-HK was significantly increased (p = 0.0028) compared with that in the Control group. The grip strength on the right and left hands of the subjects was significantly increased (p = 0.0002 and p = 0.0140, respectively) in the TWK10-HK compared with that in the Control group. Administration of heat-killed TWK10 resulted in a significant increase (p = 0.0275) in muscle weight. After 6-week administration, serum lactate, and ammonia levels were significantly lower in the TWK10-HK group than in the Control group during the exercise and recovery periods. These findings demonstrate that heat-killed TWK10 has significant potential to be used as a postbiotic for humans.