Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis.

2022-03
Journal of ginseng research 46(2)
- Soo Hyun Park
- Sangwon Chung
- Min-Yu Chung
- Hyo-Kyoung Choi
- Jin-Taek Hwang
- Jae Ho Park

PubMed: 35509826
DOI: 10.1016/j.jgr.2021.10.002

Study Design

Type: Review
Sample size: n = 23
Population: healthy adults to those with diabetes, hypertension, obesity, and/or hyperlipidemia
Methods: Systematic review and meta-analysis of 23 papers (27 datasets) investigating P. ginseng supplementation (dose 200 mg to 8 g, duration 4 to 24 weeks) on metabolic parameters
Duration: 4 to 24 weeks

Panax ginseng is a medicinal plant is a material with various pharmacological activities and research suggests that it is particularly effective in representative metabolic diseases such as hyperglycemia, hypertension, and hyperlipidemia. Therefore, in this study, systematic review and meta-analysis were performed to investigate the comprehensive effect of P. ginseng on metabolic parameters representing these metabolic diseases. A total of 23 papers were collected for inclusion in the study, from which 27 datasets were collected. The investigational products included P. ginseng and Korean Red ginseng. Across the included studies, the dose ranged from 200 mg to 8 g and the supplementation period lasted from four to 24 weeks. The study subjects varied from healthy adults to those with diabetes, hypertension, obesity, and/or hyperlipidemia. As a result of the analysis, the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group. In conclusion, P. ginseng supplementation may act as an adjuvant to prevent the development of metabolic diseases by improving markers related to blood glucose, blood pressure, and blood lipids.

Research Insights

Panax Ginseng→Reduced Blood Cholesterol
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g
Panax Ginseng→Reduced Blood Glucose Levels
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Moderate
Dose
200 mg to 8 g
Panax Ginseng→Reduced Body Fat
As a result of the analysis, the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group.
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g daily
Panax Ginseng→Reduced Diastolic Blood Pressure
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g
Panax Ginseng→Reduced Glucose Area Under the Curve
As a result of the analysis, the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group.
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g daily
Panax Ginseng→Reduced Insulin Area Under the Curve
As a result of the analysis, the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group.
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g daily
Panax Ginseng→Reduced Low-Density Lipoprotein Level
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g
Panax Ginseng→Reduced Systolic Blood Pressure
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g
Panax Ginseng→Reduced Triglyceride Levels
the levels of glucose and insulin area under the curves, % body fat, systolic and diastolic blood pressures, total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly reduced in the P. ginseng group as compared with in the placebo group
Effect
Beneficial
Effect size
Small
Dose
200 mg to 8 g