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Effects of intraduodenal injection of Lactobacillus brevis SBC8803 on autonomic neurotransmission and appetite in rodents

  • 2013-02
  • Neuroscience Letters 539
    • Y. Horii
    • Y. Nakakita
    • Y. Fujisaki
    • Saori Yamamoto
    • Nanako Itoh
    • K. Miyazaki
    • H. Kaneda
    • K. Oishi
    • T. Shigyo
    • K. Nagai

Abstract

Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food intake. To determine the function of Lactobacillus brevis (SBC8803), its effect on food intake was examined by providing food containing heat-killed SBC8803 to mice. We observed that administration of SBC8803 elevated food intake. Because the afferent intestinal vagal nerve (IVN) is hypothesized to be involved in efferent-GVNA changes, we examined the effect of intraduodenal administration of heat-killed SBC8803 on efferent-GVNA and afferent-IVN activity (IVNA) in rats. In this study, we found that intraduodenal administration of heat-killed SBC8803 increased both efferent-GVNA and afferent-IVNA in rats. Moreover, IV administration of the serotonin 3 receptor antagonist granisetron eliminated the effects of SBC8803 on efferent-GVNA and afferent-IVNA. These findings suggest that heat-killed SBC8803 enhances appetite by elevating digestion and absorption abilities via changes in autonomic neurotransmission that might be mediated by the serotonin 3 receptor.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus brevis MAK11L82BIncreased Short-Term Food IntakeBeneficial
Moderate
Lactobacillus brevis SBC8803Enhanced Autonomic FunctionBeneficial
Moderate
Lactobacillus brevis SBC8803Increased Short-Term Food IntakeBeneficial
Moderate

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