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Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial

  • 2021-01-14
  • Obesity Surgery 31(5)
    • Marília Rizzon Zaparolli Ramos
    • Lígia de Oliveira Carlos
    • Nathalia Ramori Farinha Wagner
    • I. Felicidade
    • Magda Rosa Ramos da Cruz
    • C. Taconeli
    • R. Fernandes
    • A. J. Filho
    • A. Campos


Studies have suggested that Roux-en-Y gastric bypass (RYGB) causes changes in the intestinal microbiota composition and function due to anatomical and physiological modifications. The role of probiotic supplementation after bariatric procedures remains to be determined.

Purpose: The aim of this study was to investigate the effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation on nutritional and metabolic parameters after RYGB.

Materials and methods: This is a randomized, double-blind, placebo-controlled clinical trial. Patients were assigned to receive either a probiotic supplement (FloraVantage®) or placebo for three consecutive months, beginning 7 days after surgery. Anthropometric and biochemical indexes were evaluated in the preoperative period and at the end of the study.

Results: Following RYGB, serum 25-OH vitamin D increased in both groups compared to baseline; however, this increase was significant only in the probiotic group (p = 0.004). Vitamin B12 levels tended to be higher in the probiotic group compared to the placebo group (p = 0.063), and triglyceride levels showed a significant reduction in the probiotic group only (p < 0.001). In addition, a significant reduction was observed in the anthropometric parameters and glycemic profile (p < 0.05) in both groups.

Conclusion: Probiotic supplementation after RYGB improves the vitamin and lipid profile.

Keywords: Bariatric surgery; Probiotics; Roux-en-Y gastric bypass.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis Bi-07Increased Serum 25-OH Vitamin D LevelsBeneficial
Bifidobacterium lactis Bi-07Increased Vitamin B12 LevelsBeneficial
Bifidobacterium lactis Bi-07Reduced Triglyceride LevelsBeneficial

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