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Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on Hepatic Steatosis in Zucker Rats

  • 2014-05-22
  • PLoS ONE 9(5)
    • J. Plaza-Díaz
    • C. Gómez-Llorente
    • F. Abadía-Molina
    • M. J. Sáez-Lara
    • L. Campaña‐Martín
    • S. Muñoz-Quezada
    • F. Romero
    • Á. Gil
    • L. Fontana

Abstract

We have previously described the safety and immunomodulatory effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 in healthy volunteers. The scope of this work was to evaluate the effects of these probiotic strains on the hepatic steatosis of obese rats. We used the Zucker rat as a genetic model of obesity. Zucker-Lepr(fa/fa) rats received one of three probiotic strains, a mixture of L. paracasei CNCM I-4034 and B. breve CNCM I-4035, or a placebo for 30 days. An additional group of Zucker-lean+/fa rats received a placebo for 30 days. No alterations in intestinal histology, in the epithelial, lamina propria, muscular layers of the ileal or colonic mucosa, or the submucosae, were observed in any of the experimental groups. Triacylglycerol content decreased in the liver of Zucker-Lepr(fa/fa) rats that were fed L. rhamnosus, B. breve, or the mixture of B. breve and L. paracasei. Likewise, the area corresponding to neutral lipids was significantly smaller in the liver of all four groups of Zucker-Lepr(fa/fa) rats that received probiotics than in rats fed the placebo. Zucker-Lepr(fa/fa) rats exhibited significantly greater serum LPS levels than Zucker-lean+/fa rats upon administration of placebo for 30 days. In contrast, all four groups of obese Zucker-Lepr(fa/fa) rats that received LAB strains exhibited serum LPS concentrations similar to those of Zucker-lean+/fa rats. Serum TNF-α levels decreased in the Zucker-Lepr(fa/fa) rats that received B. breve, L. rhamnosus, or the mixture, whereas L. paracasei feeding decreased IL-6 levels in the serum of Zucker-Lepr(fa/fa) rats. In conclusion, the probiotic strains reduced hepatic steatosis in part by lowering serum LPS, and had an anti-inflammatory effect in obese Zucker rats.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve R0070Reduced Hepatic SteatosisBeneficial
Moderate
Bifidobacterium breve R0070Reduced Serum LPS LevelsBeneficial
Moderate
Bifidobacterium breve R0070Reduced Serum TNF-α LevelsBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Hepatic SteatosisBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Serum LPS LevelsBeneficial
Moderate
Bifidobacterium breve SD5206Reduced TNF-α LevelsBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced Hepatic SteatosisBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced Serum IL-6 LevelsBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced TNF-α LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Serum LPS LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Serum TNF-α LevelsBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced Serum LPS LevelsBeneficial
Moderate
Lactobacillus paracasei HA-196Reduced Serum TNF-Alpha LevelBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Serum IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced Serum IL-6 LevelsBeneficial
Moderate
Lactobacillus paracasei UALpc-04Reduced TNF-α LevelsBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Reduced Hepatic Neutral LipidsBeneficial
Large
Lactobacillus rhamnosus DSM 6594Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus rhamnosus DSM 6594Reduced Serum TNF-α LevelsBeneficial
Moderate
Lactobacillus rhamnosus LBV96Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus rhamnosus LBV96Reduced Serum LPS LevelsBeneficial
Moderate
Lactobacillus rhamnosus LBV96Reduced Serum TNF-α LevelsBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced TNF-α LevelsBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced Hepatic SteatosisBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced Plasma Lipopolysaccharide LevelsBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced TNF-α LevelsBeneficial
Moderate

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