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Effects of Lactobacillus salivarius isolated from feces of fast-growing pigs on intestinal microbiota and morphology of suckling piglets

  • 2021-03-24
  • Scientific Reports 11(1)
    • J. Moturi
    • K. Kim
    • A. Hosseindoust
    • Jun Hyung Lee
    • B. Xuan
    • Jongbin Park
    • E. Kim
    • J. S. Kim
    • B. Chae

Abstract

The study determined the effects of Lactobacillus salivarius (LS) administered early in the life of suckling piglets on their growth performance, gut morphology, and gut microbiota. Thirty litters of 3-day-old crossbreed piglets were randomly assigned to one of the three treatments, and treatments were commenced on day 3 after birth. During the whole period of the experiment, the piglets were kept with their mothers and left to suckle ad libitum while being supplemented with a milk formula with or without the bacterial probiotic supplemented. The control group (CON) was not treated with probiotics, the HLS group was treated with LS144 (HLS) screened from feces of fast-growing pigs with high body mass index (BMI) while the NLS group was supplemented with LS160 (NLS) screened from feces obtained from pigs of normal BMI. At the weaning time, a higher abundance of Actinobacteria, Lentisphaerae, and Elusimicrobia phyla were observed in NLS piglets, whereas the abundance of Fibrobacteres phylum was significantly reduced in NLS and HLS piglets compared with the CON. A greater abundance of Lactobacillus was detected in the HLS treatment compared with the CON. The abundance of Bacteroides and Fibrobacter was higher in the CON piglets compared with the HLS and NLS piglets. Compared with the CON group, the oral administration of LS significantly increased the number of Lactobacillus and villus height in the duodenum, jejunum, and ileum. Moreover, the villus height of the duodenum was significantly improved in the HLS treatment compared with the NLS treatment. Based on the findings in the neonatal piglet model, we suggest that oral supplementation of LS, particularly LS isolated from high BMI pigs, could be beneficial by improving the intestinal villus height.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusImproved Intestinal Villus HeightBeneficial
Large
Lactobacillus SalivariusIncreased Beneficial Gut BacteriaBeneficial
Moderate
Lactobacillus SalivariusIncreased Villus HeightBeneficial
Large
Lactobacillus SalivariusReduced Abundance of Harmful BacteriaBeneficial
Moderate
Lactobacillus salivarius BLIS K12Improved Villus HeightBeneficial
Large
Lactobacillus salivarius BLIS K12Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Gut MorphologyBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Lactobacillus AbundanceBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Villus Height in DuodenumBeneficial
Large
Lactobacillus salivarius HA-118Improved Villus HeightBeneficial
Large
Lactobacillus salivarius HA-118Increased Lactobacillus CountsBeneficial
Large
Lactobacillus salivarius SD-5208Improved Intestinal Villus HeightBeneficial
Large
Lactobacillus salivarius SD-5208Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius SD-5851Improved Intestinal Villus HeightBeneficial
Large
Lactobacillus salivarius SD-5851Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius UALb-07Improved Duodenum Villus HeightBeneficial
Moderate
Lactobacillus salivarius UALb-07Improved Gut Microbiota DiversityBeneficial
Moderate
Lactobacillus salivarius UALb-07Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius UALs07Improved Intestinal Villus HeightBeneficial
Large
Lactobacillus salivarius UALs07Increased Duodenal Villus HeightBeneficial
Moderate
Lactobacillus salivarius UALs07Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius UALs07 UASImproved Abundance of Beneficial BacteriaBeneficial
Large
Lactobacillus salivarius UALs07 UASImproved Intestinal Villus HeightBeneficial
Large
Lactobacillus salivarius VPro 15Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius VPro 15Increased Villus HeightBeneficial
Large
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