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Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice

  • 2018-05-15
  • International Immunology 30(7)
    • Yuki Usui
    • Y. Kimura
    • T. Satoh
    • Naoki Takemura
    • Yasuo Ouchi
    • Hiroko Ohmiya
    • Kyosuke Kobayashi
    • Hiromi Suzuki
    • Satomi Koyama
    • S. Hagiwara
    • Hirotoshi Tanaka
    • S. Imoto
    • G. Eberl
    • Y. Asami
    • K. Fujimoto
    • S. Uematsu

Abstract

The gut is an extremely complicated ecosystem where micro-organisms, nutrients and host cells interact vigorously. Although the function of the intestine and its barrier system weakens with age, some probiotics can potentially prevent age-related intestinal dysfunction. Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, which are the constituents of LB81 yogurt, are representative probiotics. However, it is unclear whether their long-term intake has a beneficial influence on systemic function. Here, we examined the gut microbiome, fecal metabolites and gene expression profiles of various organs in mice. Although age-related alterations were apparent in them, long-term LB81 yogurt intake led to an increased Bacteroidetes to Firmicutes ratio and elevated abundance of the bacterial family S24-7 (Bacteroidetes), which is known to be associated with butyrate and propanoate production. According to our fecal metabolite analysis to detect enrichment, long-term LB81 yogurt intake altered the intestinal metabolic pathways associated with propanoate and butanoate in the mice. Gene ontology analysis also revealed that long-term LB81 yogurt intake influenced many physiological functions related to the defense response. The profiles of various genes associated with antimicrobial peptides-, tight junctions-, adherens junctions- and mucus-associated intestinal barrier functions were also drastically altered in the LB81 yogurt-fed mice. Thus, long-term intake of LB81 yogurt has the potential to maintain systemic homeostasis, such as the gut barrier function, by controlling the intestinal microbiome and its metabolites.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus bulgaricus LB42Enhanced Immune FunctionBeneficial
Large
Lactobacillus bulgaricus LB42Increased Abundance of Bacterial Family S24-7 (Bacteroidetes)Beneficial
Moderate
Lactobacillus bulgaricus LB42Increased Bacteroidetes to Firmicutes RatioBeneficial
Moderate
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