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Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers.

  • 2003-07
  • Journal of Dairy Science 86(7)
    • J. Xiao
    • S. Kondo
    • N. Takahashi
    • K. Miyaji
    • K. Oshida
    • A. Hiramatsu
    • K. Iwatsuki
    • S. Kokubo
    • A. Hosono

Abstract

The effects of milk products fermented by Bifidobacterium longum strain BL1, a probiotic strain, on blood lipids in rats and humans were studied. Rats were fed a cholesterol-enriched experimental diet, supplemented with lyophilized powders of 1) acid milk (control), 2) milk fermented with a mixed culture of ordinary yogurt starters composed of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL), and 3) bifidobacterium milk fermented with the probiotic B. longum strain BL1, respectively. The bifidobacterium milk feeding brought about significant lowering of the serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, in comparison with the control, while no change in high-density lipoprotein cholesterol concentration was observed. On the other hand, supplementation with SL milk resulted in only slight, nonsignificant decreases in serum lipid concentrations in comparison with the control. In the human study, 32 subjects with serum total cholesterol ranging from 220 to 280 mg/dl were randomly assigned to two treatments: 1) intake of a low-fat drinking yogurt prepared with ordinary yogurt starters composed of S. thermophilus and L. delbrueckii subsp. bulgaricus (P-group) and 2) intake of a low-fat drinking yogurt prepared with the two ordinary yogurt starters plus B. longum strain BL1 (B-group). After intake for 4 wk at 3 x 100 ml/day, reduction of serum total cholesterol was observed in approximately half of the B-group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl). However, the serum lipid concentrations in the P-group subjects were almost stable during the experimental periods. The present results indicate the potential of the probiotic B. longum strain BL1 in serum lipid improvement.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis/longumReduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium lactis/longumReduced Total CholesterolBeneficial
Large
Bifidobacterium lactis/longumReduced TriglyceridesBeneficial
Large
Bifidobacterium longum B1-05Reduced LDL CholesterolBeneficial
Large
Bifidobacterium longum B1-05Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum B1-05Reduced TriglyceridesBeneficial
Large
Bifidobacterium longum BI-05Improved Lipid ProfileBeneficial
Large
Bifidobacterium longum BI-05Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum BL03Reduced LDL Cholesterol LevelsBeneficial
Large
Bifidobacterium longum BL03Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum BL03Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum HA-135Reduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum HA-135Reduced Total CholesterolBeneficial
Large
Bifidobacterium longum HA-135Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum HA-135Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum HA-135Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Bifidobacterium longum iVE-15Reduced Serum Cholesterol LevelsBeneficial
Large
Bifidobacterium longum iVE-15Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum iVE-15Reduced TriglyceridesBeneficial
Large
Bifidobacterium longum KABP-042Reduced LDL CholesterolBeneficial
Large
Bifidobacterium longum KABP-042Reduced Serum Total CholesterolBeneficial
Moderate
Bifidobacterium longum KABP-042Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum KABP-042Reduced Serum TriglyceridesBeneficial
Moderate
Bifidobacterium longum MAK34B12LReduced LDL CholesterolBeneficial
Large
Bifidobacterium longum MAK34B12LReduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum MAK34B12LReduced TriglyceridesBeneficial
Large
Bifidobacterium longum MM-2Reduced LDL CholesterolBeneficial
Large
Bifidobacterium longum MM-2Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum MM-2Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum MM-2Stable HDL Cholesterol LevelsNeutral
Small
Bifidobacterium longum Rosell-175Reduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum Rosell-175Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum Rosell-175Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum Rosell-175Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Bifidobacterium longum Rosell-175 MEImproved Serum LipidsBeneficial
Moderate
Bifidobacterium longum Rosell-175 MEReduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum Rosell-175 MEStable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Bifidobacterium longum SD-5588Reduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum SD-5588Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum SD-5588Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum SP54Reduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum SP54Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum SP54Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum subsp. longumReduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum subsp. longumReduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum subsp. longumReduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum subsp. longum 35624Improved Lipid ProfileBeneficial
Large
Bifidobacterium longum subsp. longum 35624Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum subsp. longum UABI-14Improved Lipid ProfileBeneficial
Large
Bifidobacterium longum subsp. longum UABI-14Reduced Serum Total CholesterolBeneficial
Moderate
Bifidobacterium longum subsp. longum UABI-14Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Bifidobacterium longum UABI-14Reduced LDL CholesterolBeneficial
Large
Bifidobacterium longum UABI-14Reduced Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum UABI-14Reduced TriglyceridesBeneficial
Large
Bifidobacterium longum UABI-14Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Bifidobacterium longum UABl-14Reduced Low-Density Lipoprotein LevelBeneficial
Large
Bifidobacterium longum UABl-14Reduced Serum Total Cholesterol LevelsBeneficial
Large
Bifidobacterium longum UABl-14Reduced Triglyceride LevelsBeneficial
Large
Bifidobacterium longum UABl-14Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small

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