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Effects of milk protein concentrate supplementation on metabolic parameters, adipocytokines and body composition in obese women under weight-loss diet: study protocol for a randomised controlled trial.

  • 2022-10
  • BMJ open 12(10)
    • Fatemeh Haidari
    • Mahsa Elahikhah
    • Sheikh Mohammed Shariful Islam
    • Majid Mohammadshahi
    • Hajieh Shahbazian
    • Vahideh Aghamohammadi

Study Design

Type
Randomized Controlled Trial (RCT)
Population
44 premenopausal obese women on a weight-loss diet
Methods
2-month open-label, parallel-group, randomised controlled trial of milk protein concentrate (MPC) supplementation
Blinding
Open-label
Duration
2-month
Funding
Unclear

Introduction

Obesity impairs metabolic function and increases the risk of cardiovascular disease and type 2 diabetes mellitus. Evidence suggests that high-protein diets help to increase weight loss and protect against weight gain. Milk protein concentrate (MPC) is a dairy product with a high protein content with a ratio of casein and whey protein similar to skim milk. This trial aims to evaluate the effect of MPC supplementation in obese women under a weight-loss diet.

Methods and analysis

We will conduct a 2-month open-label, parallel-group, randomised controlled trial to determine the effect of MPC supplementation on levels of glycaemic and lipid profile, leptin, adiponectin, appetite, waist circumference, body mass index and body composition in 44 premenopausal obese women on a weight-loss diet.

Ethics and dissemination

This protocol, approved by the Medical Ethics Committee of Ahvaz University of Medical Sciences, is in accordance with the Declaration of Helsinki (approval number: IR.AJUMS.REC.1399.795). The trial results will be published in peer-reviewed journals.

Trial registration number

Iranian Registry of Clinical Trials (IRCT20201223049804N1).

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