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Abstract

This study compared the efficacy of Pediococcus acidilactici, mannan-oligosaccharide, butyric acid, and their combination on growth performance and intestinal health in broiler chickens challenged with S. Typhimurium. Ross 308 male broilers (n = 420) were randomly assigned to one of the 6 treatments, resulting in 5 replicate pens of 14 chicks per treatment. The treatments included a negative control [(NC), no additive, not challenged]; positive control [(PC), no additive, but challenged with S. Typhimurium at d 3 posthatch], and 4 groups whereby birds were challenged with S. Typhimurium at d 3 posthatch and fed diets supplemented with either probiotic [0.1 g/kg Pediococcus acidilactici (PA)], prebiotic [2 g/kg mannan-oligosaccharides (MOS)], organic acid [0.5 g/kg butyric acid (BA)], or a combination of the 3 additives (MA). The S. Typhimurium challenge decreased feed intake, body weight gain and increased feed conversion ratio and reduced jejunum villus height (VH) and VH to crypt depth (CD) ratio (P < 0.05). Birds on the MA treatment exhibited similar performance to birds on the NC treatment (P > 0.05) and had a lower population of Salmonella in the ceca compared with birds on the PC treatment, at d 14 and 21 post-challenge (P < 0.05). The lowest heterophil to lymphocyte ratio was observed in birds on the MA and NC treatments (P < 0.05). Birds fed diets supplemented with MA or PA had greater VH and VH: CD ratio than birds on the PC treatment at d 7, 14 and 21 d post-challenge (P < 0.05). Suppressed amylase and protease activity was observed as a result of the S. Typhimurium challenge; the enzyme levels were restored in birds fed the additive-supplemented diets, when compared to the birds on the PC treatment, particularly at d 21 post-challenge (P < 0.05). These results indicate that dietary supplementation with a combination of PA, BA, and MOS in broiler chickens could be used as an effective tool for controlling S. Typhimurium and promoting growth performance.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Pediococcus acidilacticiImproved Intestinal FunctionBeneficial
Moderate
Pediococcus acidilacticiReduced Heterophil-to-Lymphocyte RatioBeneficial
Moderate
Pediococcus acidilacticiReduced Salmonella PopulationBeneficial
Large
Pediococcus acidilactici KABP™-021Improved Enzyme ActivityBeneficial
Moderate
Pediococcus acidilactici KABP™-021Improved Intestinal FunctionBeneficial
Moderate
Pediococcus acidilactici KABP™-021Reduced Inflammatory ResponseBeneficial
Moderate
Pediococcus acidilactici KABP™-021Reduced Salmonella PopulationBeneficial
Large
Pediococcus acidilactici MAK92P26AImproved Enzyme ActivityBeneficial
Moderate
Pediococcus acidilactici MAK92P26AImproved Gastrointestinal HealthBeneficial
Moderate
Pediococcus acidilactici MAK92P26AImproved Immune ResponseBeneficial
Moderate
Pediococcus acidilactici MAK92P26AReduced Salmonella PopulationBeneficial
Large
Pediococcus acidilactici R1001Improved Growth PerformanceBeneficial
Large
Pediococcus acidilactici R1001Improved Intestinal FunctionBeneficial
Moderate
Pediococcus acidilactici R1001Reduced Stress IndicatorsBeneficial
Moderate
Pediococcus acidilactici R1001Restored Digestive Enzyme ActivityBeneficial
Moderate
Pediococcus acidilactici VPro29Improved Gastrointestinal HealthBeneficial
Moderate
Pediococcus acidilactici VPro29Improved Growth PerformanceBeneficial
Large
Pediococcus acidilactici VPro29Normalized Stress ResponseBeneficial
Moderate
Pediococcus acidilactici VPro29Restored Digestive Enzyme ActivityBeneficial
Moderate

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