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Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis.

  • 2023-03-28
  • Nutrients 15(7)
    • Enav Yefet
    • Liron Bar
    • Ido Izhaki
    • Rula Iskander
    • Manal Massalha
    • Johnny S Younis
    • Zohar Nachum

Study Design

Type
Meta-Analysis
Sample size
n = 854
Population
women with gestational diabetes mellitus (GDM)
Methods
systematic review and meta-analysis of randomized controlled trials; 14 (n = 854 women) met the inclusion criteria and were analyzed
  • Rigorous Journal

Objectives

To assess the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM) by performing a systematic review and meta-analysis of randomized controlled trials. The primary outcome was glycemic control, i.e., serum glucose and insulin levels. Secondary outcomes were maternal weight gain, neonatal birth weight, and lipid parameters. Weighted mean difference (WMD) was used. Cochrane's Q test of heterogeneity and I2 were used to assess heterogeneity.

Results

Of the 843 papers retrieved, 14 (n = 854 women) met the inclusion criteria and were analyzed. When compared with placebo, women receiving probiotic supplements had significantly lower mean fasting serum glucose, fasting serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, and VLDL levels. Decreased neonatal birth weight was witnessed in supplements containing Lactobacillus acidophilus.

Conclusion

Probiotic supplements may improve glycemic control and lipid profile and reduce neonatal birth weight in women with GDM.

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