Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects
- 2023-04-11
- Frontiers in Nutrition 10
- G. Pagliai
- M. Coman
- S. Baldi
- M. Dinu
- G. Nannini
- E. Russo
- Lavinia Curini
- B. Colombini
- S. Lotti
- M. Pallecchi
- L. Di Gloria
- G. Bartolucci
- M. Ramazzotti
- M. Verdenelli
- F. Sofi
- A. Amedei
- PubMed: 37125045
- DOI: 10.3389/fnut.2023.1142527
Abstract
Background and aim: In recent decades, obesity prevalence has reached epidemic proportions and considering the pivotal role of gut microbiota (GM) in the regulation of energy balance, alternative non-pharmacological approaches involving probiotics' administration have been proposed. The aim of the present study was to evaluate the effect of Lactiplantibacillus plantarum IMC 510® supplementation on anthropometric and biochemical parameters, GM composition and functionality, and gastrointestinal and general symptoms of overweight/obese subjects.
Methods: Forty overweight/obese subjects were randomly assigned to daily consume the probiotic Lactiplantibacillus plantarum IMC 510® or placebo for 3 months. Before and after the administration period, anthropometric and biochemical parameters, self-administered questionnaires, and plasma and stool samples were obtained from each participant. The GM characterization was performed with 16S rRNA sequencing, while fecal short (SCFAs) and medium (MCFAs) chain fatty acids were analyzed with a gas chromatography-mass spectrometry protocol.
Results: Compared to placebo, probiotic supplementation determined a significant decrease in body weight, BMI, waist circumference, waist-to-height ratio, and blood glucose. Moreover, probiotic administration produced a significant decrease of the genera Hafnia-Obesumbacterium and Romboutsia and an increase of Succiniclasticum spp.; conversely, placebo administration resulted in the decrease of Actinomycetaceae and an increase of both Alloprevotella spp. and of the levels of pro-inflammatory hexanoic and heptanoic acids.
Conclusion: Thanks to its effect in increasing some beneficial gut bacteria and lowering effects on waist circumference, fasting glucose levels and gastrointestinal symptoms of obese subjects, Lactiplantibacillus plantarum IMC 510® supplementation could represent a future and encouraging strategy for the prevention or treatment of obesity.
Keywords: Lactiplantibacillus plantarum IMC 510®; clinical trial; gut microbiota; obesity; probiotic supplementation.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactiplantibacillus plantarum | Altered Gut Microbiota Composition | Beneficial | Moderate |
| Lactiplantibacillus plantarum | Improved Blood Glucose Levels | Beneficial | Moderate |
| Lactiplantibacillus plantarum | Reduced Body Mass Index | Beneficial | Moderate |
| Lactiplantibacillus plantarum | Reduced Body Weight | Beneficial | Moderate |
| Lactiplantibacillus plantarum | Reduced Gastrointestinal Symptoms | Beneficial | Moderate |
| Lactiplantibacillus plantarum | Reduced Waist Circumference | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Decreased Hafnia-Obesumbacterium Genus | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Increased Beneficial Gut Microbiota | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Reduced Body Mass Index | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Reduced Body Weight | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Reduced Genera Romboutsia | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Reduced Serum Glucose Levels | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-022 | Reduced Waist Circumference | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Improved Gut Microbiome Composition | Beneficial | Large |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Body Mass Index | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Body Weight | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Pro-Inflammatory Fatty Acids | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Serum Glucose Levels | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Waist Circumference | Beneficial | Moderate |
| Lactiplantibacillus plantarum KABP™-023 | Reduced Waist-to-Height Ratio | Beneficial | Moderate |