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Effects of the probiotic strain Lactobacillus johnsonii strain La1 on autonomic nerves and blood glucose in rats.

  • 2006-10
  • Life Sciences 79(20)
    • T. Yamano
    • M. Tanida
    • A. Niijima
    • Keiko Maeda
    • Nobuaki Okumura
    • Y. Fukushima
    • K. Nagai


Oral administration of Lactobacillus casei reportedly reduces blood glucose concentrations in a non-insulin-dependent diabetic KK-Ay mouse model. In order to determine if other lactobacillus strains affect glucose metabolism, we evaluated the effect of the probiotic strain Lactobacillus johnsonii La1 (LJLa1) strain on glucose metabolism in rats. Oral administration of LJLa1 via drinking water for 2 weeks inhibited the hyperglycemia induced by intracranial injection of 2-deoxy-D-glucose (2DG). We found that the hyperglucagonemic response induced by 2DG was also suppressed by LJLa1. Oral administration of LJLa1 for 2 weeks also reduced the elevation of blood glucose and glucagon levels after an oral glucose load in streptozotocin-diabetic rats. In addition, we recently observed that intraduodenal injection of LJLa1 reduced renal sympathetic nerve activity and enhanced gastric vagal nerve activity, suggesting that LJLa1 might affect glucose metabolism by changing autonomic nerve activity. Therefore, we evaluated the effect of intraduodenal administration of LJLa1 on adrenal sympathetic nerve activity (ASNA) in urethane-anesthetized rats, since the autonomic nervous system, including the adrenal sympathetic nerve, may be implicated in the control of the blood glucose levels. Indeed, we found that ASNA was suppressed by intraduodenal administration of LJLa1, suggesting that LJLa1 might improve glucose tolerance by reducing glucagon secretion via alteration of autonomic nerve activities.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus johnsonii LJ09Enhanced Vagal Nerve Activity in the StomachBeneficial
Lactobacillus johnsonii LJ09Improved Blood Glucose LevelsBeneficial
Lactobacillus johnsonii LJ09Improved Glucose ToleranceBeneficial
Lactobacillus johnsonii LJ09Reduced Hyperglucagonemic ResponseBeneficial
Lactobacillus johnsonii LJ09Reduced Renal Sympathetic ActivityBeneficial
Lactobacillus johnsonii LJ09Suppressed Adrenal Sympathetic Nerve ActivityBeneficial
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