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Lactococcus lactis (L. lactis)a probiotics microorganism having wide range of benefits on human health, and also protects the body from pathogenic microorganism. This study was conducted to determine the co-culture effect with the probiotic strain L. lactis (MTCC440) on Salmonella enterica serovar Typhi (S.Typhi). The existing problem was to determine the individual growth of both strains during co-culture. Growth kinetics study was performed and observed for 28 h and used to determine specific growth rate of S. Typhi under co-culture study. In growth kinetics study maximum specific growth rate (μ) of S. Typhi under monoculture and co-culture study was achieved 0.695 h-1 and 0.35 h-1 respectively. The maximum cell mass of L. lactis and S. Typhi was obtained 0.15 g/L and 0.18 g/L respectively. In co-culture study, L. lactis was found effective for the inhibition of 73% growth of S. Typhi due to lactic acid production.

Keywords: Co-culture; Growth kinetics; L. lactis; Probiotics; S. Typhi.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactococcus lactisReduced Pathogen GrowthBeneficial
Lactococcus lactis L1A-23Reduced S. Typhi GrowthBeneficial
Lactococcus lactis VPro 34Reduced S. Typhi GrowthBeneficial
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