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Effects of vitamin K administration on liver function, inflammation, and coagulation in chronic viral hepatitis: a retrospective study.

  • 2026-04-01
  • Journal of medicine and life 19(4)
    • Magdalena Lixandru
    • Ionela Maniu
    • Cosmin Ionuț Lixandru
    • Florin Grosu

Study Design

Type
Observational
Sample size
n = 94
Population
94 patients with chronic viral hepatitis hospitalized between January 2020 and December 2024
Methods
Retrospective observational study; laboratory parameters assessed at admission and discharge following vitamin K administration; non-parametric tests for paired data
Duration
hospitalization (admission to discharge)
Vitamin K is essential for coagulation and has increasingly been recognized for its potential role in inflammatory processes. In patients with chronic viral hepatitis, alterations in coagulation parameters and persistent systemic inflammation are frequently observed. This study aimed to evaluate the association between vitamin K administration and changes in liver enzymes, inflammatory markers, and coagulation parameters in patients with chronic viral hepatitis. This retrospective observational study included 94 patients with chronic viral hepatitis hospitalized between January 2020 and December 2024. Laboratory parameters reflecting liver function, inflammatory status, and coagulation profile were assessed at admission and discharge following vitamin K administration. Changes in biological parameters were analyzed using non-parametric tests for paired data. Reductions in liver enzymes, inflammatory markers, and coagulation parameters were observed between admission and discharge. Aspartate aminotransferase and alanine aminotransferase levels decreased, accompanied by lower values of C-reactive protein and erythrocyte sedimentation rate. Coagulation parameters, including prothrombin time and international normalized ratio, also decreased. No significant differences were identified between patients with and without hepatitis B infection. Vitamin K administration in patients with chronic viral hepatitis was associated with changes in liver enzymes, inflammatory markers, and coagulation parameters. These findings suggest a potential role for vitamin K in the interplay between inflammation and hemostasis in chronic liver disease, while its clinical utility should be considered on an individual basis.

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