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Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses.

  • 2025-02-01
  • Asia Pacific journal of clinical nutrition 34(1)
    • Yi Chai
    • Chengyu Chen
    • Xueru Yin
    • Xinru Wang
    • Wenyan Yu
    • Haochen Pan
    • Ruiying Qin
    • Xiyue Yang
    • Qiuzhen Wang

Study Design

Type
Systematic Review
Methods
Systematic literature search in Web of science, PubMed, and Cochrane Database of Systematic Reviews from 2012 to November 2022; quality assessed using AMSTAR-2 and GRADE

Background and objectives

Growing evidence has explored the effects of water-soluble vitamins supplementation on glycemic control and insulin resistance in diabetic patients; however, the results of previous meta-analyses are inconsistent. To address this, we conducted an umbrella review to synthesize the evidence on these effects.

Methods and study design

A systematic literature search in Web of science, PubMed, and Cochrane Database of Systematic Reviews was performed from 2012 to November 2022. he quality of the meta-analyses was assessed using AMSTAR-2 and GRADE.

Results

Fourteen systematic reviews and meta-analyses met the inclusion criteria, examining the effects of five water-soluble vitamins (B-1, B-3, biotin, B-9, and C) on glycemic control and insulin resistance. The findings suggest that vitamin C supplementation can improve glycemic control in type 2 diabetes, as indicated by reduced FBG and HbA1c, with more significant effects observed for durations longer than 30 days.

Conclusions

Insulin resistance is improved by folic acid supplementations. More well-designed individual randomized controlled trials are needed in the future, as well as meta-analysis of higher quality.

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