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Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  • 2019-02-01
  • Nutrients 11(2)
    • Yun-Ha Hwang
    • Shinwon Park
    • J. Paik
    • S. Chae
    • Dong-Hyun Kim
    • Doc-Gyun Jeong
    • Eunji Ha
    • Myeongju Kim
    • Gahae Hong
    • Soo-Hyun Park
    • Su-Jin Jung
    • Sang-Min Lee
    • Kyu-Heum Na
    • Jungyoon Kim
    • Young-Chul Chung

Abstract

Early intervention using dietary supplements may be effective in alleviating cognitive impairment among individuals with mild cognitive impairment (MCI). This study investigated the efficacy and safety of Lactobacillus plantarum C29-fermented soybean (DW2009) as a nutritional supplement for cognitive enhancement. One hundred individuals with MCI were randomly assigned to take DW2009 (800 mg/day, n = 50) or placebo (800 mg/day, n = 50) for 12 weeks. The primary outcome measure was change in the composite score of cognitive functions related to memory and attention, measured by computerized neurocognitive function tests. Associations between changes in serum brain-derived neurotrophic factor (BDNF) levels and cognitive performance for each treatment group were evaluated. Compared to the placebo group, the DW2009 group showed greater improvements in the combined cognitive functions (z = 2.36, p for interaction = 0.02), especially in the attention domain (z = 2.34, p for interaction = 0.02). Cognitive improvement was associated with increased serum BDNF levels after consumption of DW2009 (t = 2.83, p = 0.007). The results of this clinical trial suggest that DW2009 can be safely administered to enhance cognitive function in individuals with MCI. Increased serum BDNF levels after administering DW2009 may provide preliminary insight into the underlying effects of cognitive improvement, which suggests the importance of the gut-brain axis in ameliorating cognitive deficits in MCI.

Keywords: Brain-derived neurotrophic factor; Cognitive impairment; Lactobacillus plantarum C29-fermented soybean (DW2009); Mild cognitive impairment.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarumImproved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarumIncreased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum 14DImproved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum 14DIncreased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum DR7Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum DR7Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum DSM 6595Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum DSM 6596Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum HA-119Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum LP09Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum SD5209Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Safe Drug AdministrationBeneficial
Moderate
Lactobacillus plantarum SD-5209Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum SD-5209Increased Serum BDNF LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus plantarum VPro 10Increased Serum BDNF LevelsBeneficial
Moderate

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