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Abstract

Background: Only few studies have investigated the role of probiotics in the development of obesity. We aimed to determine the efficacy and safety of an intake of Lactobacillus plantarum K50 (LPK) on body fat and lipid profiles in people with obesity.

Methods: This randomized, double-blind, placebo-controlled, clinical trial involved 81 adults with a body mass index of 25-30 kg/m2 who were assigned randomly to a diet including 4 × 109 colony-forming unit of LPK or a placebo. Changes in body fat, anthropometric parameters, and biomarkers of obesity were compared using a linear mixed-effect model.

Results: After 12 weeks of treatment, body weight, fat mass, and abdominal fat area did not change significantly in the two groups. However, total cholesterol levels decreased from 209.4 ± 34.4 mg/dL to 203.5 ± 30.9 mg/dL in the LPK group, but increased from 194.7 ± 37.5 mg/dL to 199.9 ± 30.7 mg/dL in the placebo group (P = 0.037). Similarly, triglyceride levels decreased from 135.4 ± 115.8 mg/dL to 114.5 ± 65.9 mg/dL in the LPK group, with a significant difference between groups. LPK supplementation also tended to decrease leptin levels compared with placebo. It also changed the distribution of gut microbiota significantly, with an increase in L. plantarum and a decrease in Actinobacteria, both of whose changes in abundance were correlated with changes in visceral adiposity, with borderline significance.

Conclusion: A 12-week consumption of LPK reduced the total cholesterol and triglyceride levels significantly with favorable alterations in microbiota, suggesting potential benefits for controlling blood lipid profiles.

Keywords: Lactobacillus plantarum; body fat; lipid; obesity; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum LP-01Disrupted Gut Microbiota DistributionBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Blood Leptin LevelsBeneficial
Small
Lactobacillus plantarum LP-01Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum LP-01Reduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Altered Gut Microbiota CompositionNeutral
Moderate
Lactobacillus plantarum LP09Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum LP09Reduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus plantarum Lp-115Altered Gut Microbiota CompositionNeutral
Moderate
Lactobacillus plantarum Lp-115Reduced Blood Leptin LevelsBeneficial
Small
Lactobacillus plantarum Lp-115Reduced Total Cholesterol LevelsBeneficial
Moderate

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