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Efficacy and Tolerability of a Scutellaria lateriflora L. and Cistus × incanus L.-Based Chewing Gum on the Symptoms of Gingivitis: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

  • 2024-03-16
  • Nutrients 16(6)
    • Alessandro Di Minno
    • Hammad Ullah
    • Lorenza Francesca De Lellis
    • Daniele Giuseppe Buccato
    • Alessandra Baldi
    • Paola Cuomo
    • Hesham R El-Seedi
    • Shaden A M Khalifa
    • Xiang Xiao
    • Roberto Piccinocchi
    • Gaetano Piccinocchi
    • Roberto Sacchi
    • Maria Daglia

Study Design

Type
Randomized Controlled Trial (RCT)
Population
60 subjects (18-70 years) with gingivitis
Methods
double-blind, placebo-controlled clinical trial; randomized to receive two chewing gums or placebo daily for 3 months
Blinding
Double-blind
Duration
3 months
Funding
Unclear
  • Rigorous Journal
Preclinical studies have shown that the combination of Cistus × incanus L. and Scutellaria lateriflora L. extracts exerts beneficial effects on oral health against gingivitis. Thus, this study aimed to assess the tolerability of a chewing gum and its efficacy on gingivitis in a double-blind, placebo-controlled clinical trial. Enrolled subjects (n = 60, 18-70 years) were randomized to receive two chewing gums or a placebo daily for 3 months. At baseline (t0) and monthly (t1, t2, and t3) timepoints, the Quantitative Gingival Bleeding Index (QGBI), the Modified Gingival Index (MGI), and the Oral Health 15 items (OH-15)] were employed to assess potential improvements in gingivitis. Pain was self-quantified via the Visual Analogue Scale (VAS), and the Clinical Global Impression Scale for Severity of illness (CGI-S) helped in evaluating the oral general conditions. This study is listed on the ISRCTN registry. At t3, the QGBI, MGI, OH-15, VAS, and CGI-S values decreased in the treated but not in the placebo group (β = 0.6 ± 0.1, t176 = 3.680, p < 0.001; β = 0.87 ± 0.21, t115 = 4.263, p < 0.001; β = 5.3 ± 2.5, t172 = 2.086, p = 0.038; β = 3.16 ± 0.51, t88 = 6.253, p < 0.001; and β = 1.09 ± 0.32, t83 = 3.419, p < 0.001, respectively). A significant improvement in gingival health occurred after a 3-month intervention with the chewing gums containing S. lateriflora and C. incanus extracts.

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