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Abstract

A probiotic formulation combining Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33, and Bifidobacterium bifidum Rosell®-71 with fructooligosaccharides, first commercialized in China, has been sold in over 28 countries since 2002. Clinical studies with this blend of strains were conducted mainly in pediatric populations, and most were published in non-English journals. This comprehensive review summarizes the clinical studies in infants and children to evaluate the efficacy of this probiotic for pediatric indications. Literature searches for pediatric studies on Biostime® or Probiokid® (non-commercial name) in 6 international and Chinese databases identified 28 studies, which were classified by indications. Twelve studies show that the probiotic significantly increases the efficacy of standard diarrhea treatment regardless of etiology, reducing the risk of unresolved diarrhea (RR 0.31 [0.23; 0.42]; p < 0.0001) by 69%. In eight studies, the probiotic enhanced immune defenses, assessed by levels of various immune competence and mucosal immunity markers (six studies), and reduced the incidence of common infections (two studies). The probiotic improved iron deficiency anemia treatment efficacy (three studies), reducing the risk of unresolved anemia by 49% (RR 0.51 [0.28; 0.92]; p = 0.0263) and significantly reducing treatment side effects by 47% (RR 0.53 [0.37; 0.77]; p = 0.0009). Other studies support further investigation into this probiotic for oral candidiasis, eczema, feeding intolerance in premature babies, or hyperbilirubinemia in newborns.

Keywords: Biostime®; Probiokid®; children; immune defenses; infantile diarrhea; infants; newborns; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticus Rosell-52Improved Efficacy of Diarrhea TreatmentBeneficial
Large
Lactobacillus helveticus Rosell-52Improved Immune FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Iron Deficiency Anemia Treatment EfficacyBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEImproved Efficacy of Diarrhea TreatmentBeneficial
Large
Lactobacillus helveticus Rosell-52 MEImproved Immune FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEImproved Iron Deficiency Anemia Treatment EfficacyBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEReduced Side Effects in Iron Deficiency Anemia TreatmentBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Efficacy of Diarrhea TreatmentBeneficial
Large
Lactobacillus helveticus Rosell-52NDImproved Immune FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Iron Deficiency Anemia Treatment EfficacyBeneficial
Moderate

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