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Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study

  • 2007-02
  • Therapeutics and Clinical Risk Management 3(1)
    • G. Marseglia
    • M. Tosca
    • I. Cirillo
    • A. Licari
    • M. Leone
    • A. Marseglia
    • A. Castellazzi
    • G. Ciprandi

Abstract

Probiotic milk has been previously demonstrated to reduce the number of respiratory infections (RI) among children attending day care centres. Thus, this pilot study was aimed to assess the efficacy and the safety of 3 month treatment with Bacillus clausii in the prevention of recurrent respiratory infections (RRI) in children. Eighty children with RRI were studied: 40 of them were randomly treated with B. clausii for 3 months, and followed up for further 3 months; 40 were included in the control group during the same period. Children treated with B. clausii had shorter duration of RI in comparison with the control group both during the treatment phase (mean 11.7 days vs 14.37; p=0.037) and the follow-up period (mean 6.6 days vs 10.92; p=0.049). This effect was evident also in allergic children during the follow-up. In conclusion, this pilot study provides the first preliminary evidence that B. clausii may exert a significant and persistent impact on RI in children and is safe and well tolerated.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus clausiiImproved Health in Children with AllergiesBeneficial
Moderate
Bacillus clausiiReduced Duration of Respiratory Tract InfectionsBeneficial
Moderate
Bacillus clausii SNZ-1971Prevented Upper Respiratory Tract InfectionBeneficial
Moderate
Bacillus clausii SNZ-1971Reduced Duration of Respiratory Tract InfectionsBeneficial
Moderate

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