- 2025-07-25
- Frontiers in medicine 12
Study Design
- Type
- Systematic Review
- Sample size
- n = 816
- Population
- 1,816 patients with osteoporosis
- Methods
- Systematic search of PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases through March 2025 to identify eligible RCTs; meta-analysis using random-effects model
- Funding
- Unclear
Introduction
Current evidence from randomized controlled trials (RCTs) supports the anti-osteoporotic properties of Chinese Herbal Medicine (CHM); however, its therapeutic advantages over conventional treatments remain inconclusive. This study aimed to compare the therapeutic effects of CHM with those of conventional therapy in patients with osteoporosis, using a meta-analysis approach.Methods
A systematic search of PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases was conducted through March 2025 to identify eligible RCTs. The weighted mean difference (WMD) and 95% confidence intervals (CI) were used as effect estimates, with pooled analyses calculated using a random-effects model. Additional exploratory analyses included sensitivity and subgroup analyses.Results
Eighteen RCTs involving a total of 1,816 patients with osteoporosis were included in the meta-analysis. CHM was associated with increased bone mineral density (BMD) at the lumbar spine (WMD: 0.09; 95% CI: 0.04 to 0.13; p < 0.001), femoral neck (WMD: 0.09; 95% CI: 0.02 to 0.17; p = 0.015), and Ward's triangle area (WMD: 0.08; 95% CI: 0.01 to 0.15; p = 0.025). However, CHM showed no significant effect on BMD at the greater trochanter of the femur (WMD: 0.01; 95% CI: -0.03 to 0.05; p = 0.698). Additionally, CHM was not associated with changes in alkaline phosphatase (WMD: 0.98; 95% CI: -6.88 to 8.83; p = 0.808), serum calcium (WMD: 0.08; 95% CI: -0.09 to 0.25; p = 0.372), or serum phosphorus (WMD: -0.05; 95% CI: -0.22 to 0.12; p = 0.574).Conclusion
Chinese Herbal Medicine was associated with significant improvements in BMD at the lumbar spine, femoral neck, and Ward's triangle area compared to conventional therapies, though the evidence is limited by moderate study quality and high heterogeneity. The findings suggest potential benefits of CHM in specific skeletal sites, but further rigorous trials are needed to confirm efficacy.Systematic review registration
INPLASY platform (number: INPLASY202530115).