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Efficacy of Emblica Officinalis and Curcumin Longa, Two Significant Herbal Antioxidants, in the Management of OSMF: A Comparative Cross-sectional Study.

  • 2025-12
  • Journal of pharmacy & bioallied sciences 17(Suppl 4)
    • Annette M Bhambal
    • Parnavi Mishra
    • Sudhanshu Saxena
    • Palak Jain Choudhary
    • Akshay K Agarwal
    • Aparna Raj

Study Design

Type
Clinical Trial
Population
Sixty clinically diagnosed OSMF patients
Methods
Patients equally divided into Groups A and B receiving Emblica officinalis and Curcumin longa respectively, twice daily for 2 months
Duration
2 months
Funding
Unclear

Introduction

Oral submucous fibrosis (OSMF) is a persistent, potentially cancerous condition that affects 6.42 out of every 1000 people in South Asia. It causes burning sensation, limited mouth opening, and fibrosis. This study compares the efficacy of Emblica officinalis and Curcumin longa, two potent herbal antioxidants, in managing OSMF symptoms.

Materials and methods

Sixty clinically diagnosed OSMF patients were equally divided into Groups A and B who received Emblica officinalis and Curcumin longa respectively (i.e., twice daily for 2 months). Data was analyzed using the Chi-square and Student's paired t-test (P < 0.05).

Results

Group A showed greater reduction in oral burning (Visual Analogue Scale scores), while Group B exhibited significant improvement in mouth opening.

Discussion

Curcumin longa was more effective in improving mouth opening and reducing fibrous bands, for treating OSMF-related structural and functional deficits. Emblica officinalis offered more relief from the burning sensation, indicating its importance in symptomatic therapy.

Conclusion

A combination therapy may offer a more holistic approach. Future research should explore nanoparticle formulations of Curcumin longa and Emblica officinalis to enhance their therapeutic potential in OSMF and fibrosis.

Research Insights

  • Amalaki→Reduced Oral Burning

    Group A showed greater reduction in oral burning (Visual Analogue Scale scores)

    Effect
    Beneficial
    Effect size
    Small
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