Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis.
- 2022-06-30
- Medicine 101(26)
- Jianxun Zhu
- Xiaoru Xu
- Xin Zhang
- Yue Zhuo
- Shaotao Chen
- Chongwen Zhong
- Mingjun Liu
- Zhihong Wang
- PubMed: 35776997
- DOI: 10.1097/md.0000000000029767
Study Design
- Type
- Meta-Analysis
- Sample size
- n = 1,298
- Population
- adult patients with disease-related fatigue
- Methods
- search in Pubmed, Embase, Medline, Cochrane library; two independent reviewers; Review Manager 5.3 for risk of bias
Background
Ginseng has been believed to provide energy, physical health, and well-being to patients for hundreds of years. Fatigue is a multidimensional symptom with unknown etiology and varying severity, and lots of patients suffer from fatigue.Methods
We search for research of ginseng treatment of disease-related fatigue in adult patients in Pubmed, Embase, Medline, and Cochrane library. Two independent reviewers assessed included studies and met to develop consensus on included studies. And we used Review Manager 5.3 software to evaluate the risk of bias.Results
The present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44-0.22).Conclusions
The use of ginseng supplements is benefit for patients to reduce disease-related fatigue.Research Insights
ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44-0.22).
- Effect
- Beneficial
- Effect size
- Moderate