Endogenous Mechanisms of Selenium-Induced Antagonism against Cadmium Toxicity in Crops: Integration and Reconstruction of a Multilevel Defense Network.
- 2026-04-14
- Journal of agricultural and food chemistry 74(16)
- Jun Liu
- Jiajie Zhang
- Shiyu Hu
- Menglei Jiang
- Xinru Lin
- Peishuang He
- Cuiying Peng
- PubMed: 41980076
- DOI: 10.1021/acs.jafc.5c17688
Study Design
- Type
- Review
- Rigorous Journal
Selenium (Se) orchestrates a multilevel endogenous defense network in crops against cadmium (Cd) toxicity. This network operates from rhizosphere immobilization (e.g., Cd-Se complexes, microbiome interactions, iron plaque, and root exudates) and subcellular sequestration via transporter regulation (e.g., OsNramp5, OsHMA3) to antioxidant enhancement and selenoprotein activation. Critically, Se acts as a signaling initiator, engaging pathways (e.g., GATA3-COMT1-melatonin) to systemically reprogram stress responses. This review highlights that Se's antagonistic efficacy is form-, dose-, and genotype-dependent, providing a mechanistic basis for precision agronomic strategies. Future efforts must bridge laboratory findings to field applications by elucidating molecular switches and developing integrated predictive technologies.