Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment.

2025-02-18
Theranostics 15(8)
- Guangze Sang
- Bingkai Wang
- Yujie Xie
- Yu Chen
- Feng Yang

PubMed: 40093907
DOI: 10.7150/thno.103983

Study Design

Type: Review
Methods: This comprehensive review presents the latest advancements in engineering probiotic-based materials, ranging from basic treatment mechanisms to the modification techniques used in IBD management.

Inflammatory bowel disease (IBD) is a chronic condition affecting the intestines, marked by immune-mediated inflammation. This disease is known for its recurrent nature and the challenges it presents in treatment. Recently, probiotic have gained attention as a promising alternative to traditional small molecular drugs and monoclonal antibody chemotherapies for IBD. Probiotic, recognized as a "living" therapeutic agent, offers targeted treatment with minimal side effects and the flexibility for biological modifications, making them highly effective for IBD management. This comprehensive review presents the latest advancements in engineering probiotic-based materials, ranging from basic treatment mechanisms to the modification techniques used in IBD management. It delves deep into how probiotic produces therapeutic effects in the intestinal environment and discusses various strategies to enhance probiotic's efficacy, including genetic modifications and formulation improvements. Additionally, the review addresses the challenges, practical application conditions, and future research directions of probiotic-based therapies in IBD treatment, providing insights into their feasibility and potential clinical implications.

Research Insights

Bifidobacterium lactis HA-194→Improved Gastrointestinal Symptoms
consuming Bifidobacterium lactis HA-194... observed health outcomes
Effect
Beneficial
Effect size
Small
Lactobacillus helveticus HA-128→Improved Gut Health
Lactobacillus helveticus HA-128 ... significantly improved bowel symptoms, quality of life, and inflammatory response in subjects with constipation-predominant irritable bowel syndrome
Effect
Beneficial
Effect size
Small
Lactobacillus salivarius UCC118→Reduced Inflammatory Bowel Disease Symptoms
probiotic have gained attention as a promising alternative ... for IBD ... offers targeted treatment with minimal side effects ... This comprehensive review presents the latest advancements in engineering probiotic-based materials ... in IBD management.
Effect
Beneficial
Effect size
Moderate
Lactobacillus salivarius UCC118→Reduced Intestinal Inflammation
Lactobacillus salivarius UCC118 has been reported to improve disease symptoms and reduce inflammation in models of intestinal disease
Effect
Beneficial
Effect size
Moderate
Lactobacillus salivarius UCC118→Reduced Risk of Colorectal Cancer
Lactobacillus salivarius UCC118 showed a statistically significant reduction in colorectal cancer in a mouse model
Effect
Beneficial
Effect size
Moderate