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Abstract

Consumption of lactic acid bacteria (LAB) has been suggested to confer a range of health benefits including stimulation of the immune system and increased resistance to malignancy and infectious illness. In the present study, the effects of feeding Lactobacillus rhamnosus (HN001, DR20), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019, DR10) on in vivo and in vitro indices of natural and acquired immunity in healthy mice were examined. Mice were fed daily with L. rhamnosus, L. acidophilus or B. lactis (10(9) colony forming units) and their immune function was assessed on day 10 or day 28. Supplementation with L. rhamnosus, L. acidophilus or B. lactis resulted in a significant increase in the phagocytic activity of peripheral blood leucocytes and peritoneal macrophages compared with the control mice. The proliferative responses of spleen cells to concanavalin A (a T-cell mitogen) and lipopolysaccharide (a B-cell mitogen) were also significantly enhanced in mice given different LAB. Spleen cells from mice given L. rhamnosus, L. acidophilus or B. lactis also produced significantly higher amounts of interferon-gamma in response to stimulation with concanavalin A than cells from the control mice. LAB feeding had no significant effect on interleukin-4 production by spleen cells or on the percentages of CD4+, CD8+ and CD40+ cells in the blood. The serum antibody responses to orally and systemically administered antigens were also significantly enhanced by supplementation with L. rhamnosus, L. acidophilus or B. lactis. Together, these results suggest that supplementation of the diet with L. rhamnosus (HN001), L. acidophilus (HN017) or B. lactis (HN019) is able to enhance several indices of natural and acquired immunity in healthy mice.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis HN019Enhanced B-Cell ProliferationBeneficial
Large
Bifidobacterium lactis HN019Enhanced Interferon Gamma ProductionBeneficial
Large
Bifidobacterium lactis HN019Enhanced T-Cell ProliferationBeneficial
Large
Bifidobacterium lactis HN019Improved Specific Antibody ResponseBeneficial
Large
Bifidobacterium lactis HN019Increased PMN Cell Phagocytic CapacityBeneficial
Large
Lactobacillus rhamnosus NH001Enhanced Interferon Gamma ProductionBeneficial
Large
Lactobacillus rhamnosus NH001Enhanced Spleen Cell Proliferative ResponseBeneficial
Moderate
Lactobacillus rhamnosus NH001Improved Specific Antibody ResponseBeneficial
Large
Lactobacillus rhamnosus NH001Increased PMN Cell Phagocytic CapacityBeneficial
Large
Lactobacillus rhamnosus R0011Enhanced B-Cell ProliferationBeneficial
Large
Lactobacillus rhamnosus R0011Enhanced Interferon Gamma ProductionBeneficial
Large
Lactobacillus rhamnosus R0011Improved Phagocytic ActivityBeneficial
Moderate
Lactobacillus rhamnosus R0011Improved Specific Antibody ResponseBeneficial
Large
Lactobacillus rhamnosus R0011Improved T-cell Proliferative ResponseBeneficial
Moderate

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